Actin brain proteins

In addition to its influence on protein—protein interactions, phosphorylation also affects protein structure and activity. One case involves a protein termed dematin headpiece (DHP), an actin-binding protein found in a variety of tissues including heart, brain, skeletal muscle, kidney, and lung." DHP is known to interact with Ras-guanine nucleotide exchange factor (Ras-GRF2) and this interaction can modulate MARK pathways, which can link the cytoskeleton and signaling pathways." ... 

Soltysik-Espanola M, Rogers RA, Jiang S et al. Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell 1999 10(7) 236l-2375. 

Weitzdoerfer R, Fountoulakis M, Lubec G. Reduction of actin-related protein complex 2/3 in fetal Down syndrome brain. Biochem Biophys Res Commun 2002 293(2) 836-841. 

Additional information <1> (<1> isozyme of calmodulin-dependent multifunctional protein kinase II in smooth-muscle [5] <1> caldesmon is not a substrate of smooth-muscle myosin light-chain kinase [3] <1> no substrates are bovine cardiac C-protein, bovine brain fodrin, rabbit skeletal muscle glycogen synthase, phosphorylase B, troponon (I -I- T -I- C), actin, tropomyosin, smooth-muscle actin, filamin, vinculin, cr-actinin, protamine or phosvitin [1]) [1-3]... 

Malignant gliomas (astrocytomas) are lethal invasive brain tumors. Invasive cell migration is initiated by extension of pseudopodia into interstitial spaces. In a DIGE technology study (see above), pseudopodia of glioma cells were harvested and their protein profile compared with the profile of whole cells. Increased pseudopodial constituents were identified as actin,... 

Fluoroaluminate complexes can mimic the action of many hormones, neurotransmitters, and growth factors. G-protein-mediated cell responses are key steps in neurotransmission and intercellular signaling in the brain [20], and TFA acts as an active stimulatory species [21]. Exposure of osteoblasts to TFA results in a marked potentiation of intracellular orthophosphate transport, alluding to the anion s ability to increase bone mineralization [22]. Brief exposure to aluminum fluoride complexes induces prolonged enhancement of synaptic transmission [23] and can potentially affect the activity of many other ion channels and enzymes in the kidney [24]. Rapid and dynamic changes of the cytoskeletal actin network are of vital importance to the motility of many cells, and TFA induction effects a pronounced and sustained... 

Reeve SP, Bassetto L, Genova GK, Kleyner Y, Leyssen M, Jackson FR, Hassan BA (2005) The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. CurrBiol 15 1156-1163... 

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