Hepoxylins and Related Metabolites of Arachidonic Acid

Total Synthesis of Hepoxylins and Related Metabolites of Arachidonic Acid 

Hepoxylins are metabolites of arachidonic acid which arise from 12-HPETE in tissues such as pancreatic islet cells (where they stimulate glucose-dependent insulin release) and brain (where they appear to have a neuromodulatory role). The structure of the hepoxylins was confirmed by synthesis which also has provided this scarce material for biological investigation. 

Synthesis of 8-hydroxy-ll,12(S,S)-epoxyeicosa-5,14-(Z)-9-( )-trienoic acids (hepoxylins) (Ref. 1)  

Synthesis of 12-(5)-10-hydroxy-/ra/is-ll,12-epoxyeicosa-5,9,14-(Z)-trienoic acids, position isomers of hepoxylins isolated from blood platelets (Ref. 2)  

Synthesis of 5-, 11-, and 15-HETE s. Conversion of HETE s into the Corresponding HPETE s 

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