Acetophenone bromide

Acetophenone Methyl phenyl ketone 1.34 CgHgO Hydrogen bromide 226 HBr... 

Desyl bromide (a-bromo-desoxybenzoin, m-bromo-co-phenyl acetophenone) [484-50-0] M 275.2, m 57.1-57.5 . Crystd from 95% EtOH. 

The present procedure was developed from those of Wallach and Freylon, based upon the general method discovered by Leuckart. a-Phenylethylamine also can be prepared satisfactorily by the reduction of acetophenone oxime with sodium and absolute alcohol or sodium amalgam, but the reagents are more expensive and the processes less convenient. The amine has been obtained by reducing acetophenone oxime electro-lytically, by reducing acetophenone phenylhydrazone with sodium amalgam and acetic acid, from a-phenylethyl bromide and hexamethylenetetramine, and by the action of methyl-magnesium iodide upon hydrobenzamide, as well as by other methods of no preparative value. 

Acetone cyanohydrin (stabilized), 6 Acetone tliiosemicarbazide, 6 Acetonitrile, 6 Acetophenetidin, 7 Acetophenone, 7 Acetyl acetone peroxide, 7 Acetyl bromide, 7 Acetyl chloride, 7... 

The substitution of the lone proton on the benzhydryl carbon by a methyl group again affords compounds with antihistamine activity. Reaction of an appropriate acetophenone (21) with phenyl-magnesium bromide affords the desired tertiary alcohols (22). 

In much the same vein, the Mannich product from acetophenone with formaldehyde and pyrrolidine (44b) affords procyclidine (49) Dn reaction with cyclohexylmagnesium bromide. In an interesting variation, the ketone is first reacted with phenylmagnesium bromide. Catalytic hydrogenation of the carbinol (50) thus obtained iTin be stopped after the reduction of only one aromatic ring. ... 

Diacetoxy acetophenone 1 -p-Methoxyphenyl-2-benzylamino propane Hydrogen bromide... 

The starting material is prepared by the reaction of acetophenone, paraformaldehyde and pyrrolidine to give OJ-pyrrolidinopropiophenone. That is in turn reacted with phenyl magnesium bromide to give 1,1-diphenyl-3-pyrrolidinpropan-1-ol. 

Acetophenone, paraformaldehyde and diethylamine are first reacted to give CO-diethylamino-propiophenone. That is reacted with cyclohexylmagnesium bromide to give 3-diethylamino-1 -cyclohexyl-1 -phenylpropanol-1. 

Benoxinate hydrochloride Bumetanide Fluocortin butyl Pentobarbitol sodium p-n-Butoxy acetophenone Dyclonine HCI Butoxybenzyl bromide Butropium bromide 7-[D-0 -tert-Butoxycarbonylamino-a -... 

Phenyl-2-butanol has a methyl group, an ethyl group, and a phenyl group (—Cgl ) attached to the alcohol carbon atom. Thus, the possibilities arc addition of ethylmagnesium bromide to acetophenone, addition of methylmagnesium bromide to propiophenone, and addition of phenylmagnesimn bromide to 2-butanone. 

O-Acylated or mesylated oximes such as the ethyl carbonate of acetophenone-oxime 1772 react with TIS 17, with Beckmann rearrangement to the imidoyl iodide 1773, which adds phenylmagnesium bromide in situ to give 61% of the sec-... 

The Michael reaction of benzylidene acetophenone and benzylidene acetone with ethyl acetoacetate, nitromethane, and acetylacetone was studied by Musaliar and co-workers in the presence of a cetyltrimethy-lammonium bromide-containing aqueous micellar medium.50 The Michael reaction of various nitro alkanes with electrophilic alkenes is performed in NaOH (0.025-0.1 M) in the presence of cetyltrimethylam-monium chloride (CTACI) without any organic solvent (Eq. 10.23).51... 

Zinc halide complexes with acetophenone have been structurally characterized and form monomeric or polymeric structural motifs.346 The bromide and iodide derivatives are monomeric and the chloride derivative is a coordination polymer with bridging chlorides. 

R1 to R3 with yields ranging from 20% to 90%. For the reaction of acetophenone, allyl bromide can be replaced with propargyl bromide, benzyl bromide, or an a-bromoester, affording the corresponding tertiary alcohols in 86%, 86%, and 66% yields, respectively. 

Bell el al., 1974. The reference intermolecular reaction is of the anion of p-hydroxy-acetophenone with EtCOCHjBr under the same conditions As for note j except that the reference reaction is alkylation of the guaiacol anion m Borchardt and Cohen, 1972. EM s based on relative rates assuming equal EM s for the bromide and mesylate, B.5.10 and B.5.12... 

In contrast to the polyacrylamide homopolymers typical of CE,Fujimoto et al. incorporated charged functionalities into the neutral polyacrylamide chains to accelerate the migration of neutral compounds through a capillary column [90]. Despite this improvement, nearly 100 min were required to effect the separation of acetone and acetophenone, making this approach impractical even with the use of high voltage. Alternatively, Tanaka et al. [86] alkylated commercial poly-allylamine with alkyl bromides, followed by a Michael reaction with... 

Barba and coworkers [84-91] have published a number of papers dealing with novel syntheses based on the reduction of phenacyl bromides. Electrolysis of phenacyl bromide at a mercury cathode leads to an intermediate, which reacts to give 2,4-diphenylfuran [84]. However, when a proton donor (CH3OH) is present, the reduction of phenacyl bromide yields acetophenone and 2-bromo-l,3-diphenyl-3,4-epoxy-butan-l-one. Interestingly, if phenacyl bromide is slowly introduced into an electrolysis cell so that the unreduced starting material is maintained at a low concentration, the products are different [85] (Scheme 7). 

The dimer of chloro(l,5-hexadiene)rhodium is an excellent catalyst for the room temperature hydrogenation of aromatic hydrocarbons at atmospheric pressure. The reaction is selective for the arene ring in the presence of ester, amide, ether and ketone functionalities (except acetophenone). The most useful phase transfer agents are tetrabutylammonium hydrogen sulfate and cetyltrimethylammonium bromide. The aqueous phase is a buffer of pH 7.6 (the constituents of the buffer are not critical). In all but one case the reaction is stereospecific giving cis products... 

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