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Acetic acid esters, hydrolysis

Commercial Hydrolysis Process. The process of converting poly(vinyl acetate) to poly(vinyl alcohol) on a commercial scale is compHcated on account of the significant physical changes that accompany the conversion. The viscosity of the poly(vinyl acetate) solution increases rapidly as the conversion proceeds, because the resulting poly(vinyl alcohol) is insoluble in the most common solvents used for the polymeri2ation of vinyl acetate. The outcome is the formation of a gel swollen with the resulting acetic acid ester and the alcohol used to effect the transesterification. [Pg.484]

Reaction with Water. The alkyl carbonate esters, especially the lower ones, hydroly2e very slowly in water when compared to the carbonochloridic esters (chloroformates). Under alkaline conditions, the rates of hydrolysis are similar to those of the corresponding acetic acid esters. [Pg.43]

The hydrogenation in the presence of Pd/G is also effective for the d compounds to amines. The Michael addition of nitromethime to 2-alkenoic esters followed by catalytic hydrogenation using 10% Pd/G in acetic acid md hydrolysis is a convenient method for the preparation of 3-alkyl-4-aminobut moic acids, which are importimt y-amino acids for biological snidy fEq. 6.48. The reduction c m be carried out at room temperanire md atmospheric pressure. [Pg.172]

Buffet and Lamaty, 1976. The pA. -values quoted are for the corresponding methoxymethoxy-benzoic acids. The reference intramolecular reaction is the acetic acid catalysed hydrolysis of the methyl ester in each case corrected for differences in pKt using a= 0.5 (Capon and Nimmo, 1975)... [Pg.273]

Like in Chapt. 7, we begin the discussion with acetates, since acetic acid is the simplest nontoxic acyl group, formic acid being less innocuous. An informative study was carried out to compare the kinetics of hydrolysis of two types of corticosteroid esters, namely methyl steroid-21-oates (which are active per se) and acetyl steroid-21-ols (which are prodrugs), as exemplified by methyl prednisolonate (8.69) and prednisolone-21-acetate (8.70), respectively [89]. In the presence of rat liver microsomes, the rate of hydrolytic inactivation of methyl steroid-21-oates was much slower than the rate of hydrolytic activation of acetyl steroid-21-ols. Thus, while the Km values were ca. 0.1 -0.3 mM for all substrates, the acetic acid ester prodrugs and the methyl ester drugs had Vmax values of ca. 20 and 0.15 nmol min-1 mg-1, respectively. It can be postulated that the observed rates of hydrolysis were determined by the acyl moiety, in other words by the liberation of the carboxylic acid from the acyl-enzyme intermediate (see Chapt. 3). [Pg.472]

Method E, which assumes the N(7)-C(7a) bond formation in the cyclization step, is also rarely used in the synthesis of thienopyridines. For example, the method (1997H255, 1998JMC(E)33, 1998PS21) for the preparation of 4-oxo-4,7-di-hydrothieno[2,3-Z>]pyridine-5-carboxylic acid esters 54 is based on intramolecular /V-nucleophilic substitution of (E/Z)-aminomethylene derivatives of (2,5-dichloro-3-thenoyl)acetic acid esters 52 in the presence of a strong base. Esters 52 and products of their alkaline hydrolysis 56 have an antibacterial action the influence of the substituents on the biological activity of the resulting compounds was studied. [Pg.127]

Fig. 13.37. Malonic ester synthesis of alkylated acetic acids II hydrolysis and decarboxylation of the all lated malonic ester. Fig. 13.37. Malonic ester synthesis of alkylated acetic acids II hydrolysis and decarboxylation of the all lated malonic ester.
Barnett, P., Rosenberry, T.L. (1977). Catalysis of acetylcholinesterase acceleration of the hydrolysis of neutral acetic acid esters by certain aromatic cations. J. Biol. Chem. 252 7200-6. Benz, R.D. (2007). Toxicological and clinical computational analysis and the US FDA/CDER. Expert Opin. Drug Metab. Toxicol. 3 109-24. [Pg.151]

Under acidic conditions, however, the liberation of free acetic acid during hydrolysis of the esters can increase the acidity and enhance further hydrolysis of not only additional ester groups, but acetal linkages and lignin bonds as well. A prime example is the so-called autohydrolysis reaction (2) in which acetic acid liberated by steam can cause complete hydrolysis of the hemicelluloses and convert the lignin into soluble fragments. [Pg.578]

Ciubotariu, D., Deretey, E., Oprea, T.I., Sulea, T., Simon, Z., Kurunczi, L. and Chiriac, A. (1993). Multiconformational Minimal Steric Difference. Structure-Acetylcholinesterase Hydrolysis Rates Relations for Acetic Acid Esters. QuantStruct.-Act.Relat., 12,367-372. [Pg.550]

Woodward method The syn-hydroxylation of an alkene the first step involves treating the alkene with iodine and silver acetate in a 1 1 molar ratio in wet acetic acid. The hydrolysis of the intermediate c/////-P-halogenoester is via a normal SN2 reaction in which there is no neighbouring group effect because the ester function is solvated by the water. Overall //-addition may be achieved by the method of Prevost. [Pg.395]

Cellulose acetate is an ester of cellulose and acetic acid. Hence, hydrolysis takes place when the pH of the solution with which a cellulose acetate membrane is in contact is too high or too low, lowering the degree of acetylation, defined as the number of hydroxyl groups (total of three in one D-glucopyranose unit) that can be acetylated. Because a degree of acetylation above 2.5 is required for satisfactory salt rejection in seawater desalination, excessive hydrolysis results in poor membrane performance. The pH values between 5 and 7 should be maintained when cellulose acetate membranes are used. ... [Pg.2324]

The factor 2.48 puts a on the same scale as Hammett s er, and the k0 values are rate constants for acid and base hydrolysis of acetic acid esters (i.e., R is a methyl group in the reference compound). Usually R is an ethyl or methyl group, but in many cases the rate constants do not depend on the nature of R. Equation 8 is based on the fact that acid hydrolysis rates of substituted benzoic acid esters are only slightly affected by the nature of the substituent, but acid hydrolysis rates of aliphatic esters are strongly affected by substituents. These effects were taken to be caused by steric factors thus log(/c//c0)acid defines s. It is reasonable to assume that steric factors affect base-catalyzed rates in the same way. Substituent effects on base hydrolysis of aliphatic compounds are composed of both polar and steric effects, and subtraction of the latter yields a measure of the former. The parameter a is important because it allows one to evaluate substituent effects on aliphatic reaction rates by a formula analogous to the Hammett equation, or by a bivariate relationship, the Taft-Pavelich equation (Pavelich and Taft, 1957) ... [Pg.121]

Alkaline hydrolysis of formate and halo-substituted acetic acid ester manufacture of cyclohexanone oxime manufacture of dithiocarbamate , alkylation of isobutane with butenes and of toluene and xylenes with acetaldehyde (or acetylene) nitration of toluene extraction of metals. [Pg.787]

Increasing the temperature to 350 °C results in decarbonylation of the phenylpyruvic acid methyl ester derivatives and the phenyl acetic ester is formed with a ratio of 65 % a-ketoester to 35 % acetic acid ester. Until now the industrial process for the synthesis of phenylacetic acid ester has started from benzyl chloride, which is converted to benzyl cyanide by KCN, followed by hydrolysis. Every step of this reaction must be performed in a separate reactor and special measures must be taken for handling large amounts of toxic KCN. The new route is certainly an environmentally benign alternative [8,27]. [Pg.222]

Startg. arenemanganese tricarbonyl complex allowed to react with 1 eq. Schollkopf s pyrazine in THF at —78° for 30 min - intermediate complex (Y 80%), demetalated with N-bromosuccinimide in ether at room temp, for 15 min - product (Y 60% d.e. 95%). F.e. and hydrolysis to chiral amino(aryl)acetic acid esters s. A.J. Pearson et al., J. Chem. Soc. Chem. Commun. 1989, 659-61. [Pg.430]

An acetic acid ester of cellulose, obtained by the action of acetic acid or acetic anhydride on purified cellulose (e.g., from cotton Unters). All three hydroxyl groups of each glucose unit can be acetylated. For plastics applications, it is usual to acetylate fully and then lower the acetyl value to 54 2 % by partial hydrolysis. [Pg.2201]

Cellulose acetate (CA) is the acetic acid ester of cellulose. It is obtained by the action, under rigidly controlled conditions, of acetic acid anhydride on purified cellulose usually obtained from cotton linters. All three available hydroxyl groups in each glucose unit of the cellulose can be acetylated. However, in the material normally used for plastics, it is usual to acetylate fully and then to lower the acetylate value (expressed as acetic acid) to 52-56 percent by partial hydrolysis. When compounded with suitable plasticizers, this gives a tough thermoplastic material. Cellulose acetate is mainly an extrusion (film and sheet) material, but injection applications include premium toys, tool handles, appliance housings, shields, lenses, and eyeglass frames. [Pg.86]

Romanova LV, Ivanova OA, Tkachenko VN (1975) Effect of light and temperature conditions of potato tuber germination on growth, yield and hormonal activity of the plants. Fiziol Biokhim Kul t Rast 7 625-631 Rosenberry TL, Bernhard SA (1972) Studies of catalysis by acetylcholinesterase. Synergistic effects of inhibitors during the hydrolysis of acetic acid esters. Biochemistry 11 4308-4321... [Pg.75]

Ketonic hydrolysis to di-iso-propyl ketone. Mix 15 g. of the ester with 30 ml. of glacial acetic acid, 10 ml. of water and 10 ml. of concentrated sulphuric acid, and reflux in a flask coimected by a ground glass joint... [Pg.480]

Simple esters cannot be allylated with allyl acetates, but the Schiff base 109 derived from o -amino acid esters such as glycine or alanine is allylated with allyl acetate. In this way. the o-allyl-a-amino acid 110 can be prepared after hydrolysis[34]. The Q-allyl-o-aminophosphonate 112 is prepared by allylation of the Schiff base 111 of diethyl aminomethylphosphonates. [35,36]. Asymmetric synthesis in this reaction using the (+ )-A, jV-dicyclohex-ylsulfamoylisobornyl alcohol ester of glycine and DIOP as a chiral ligand achieved 99% ec[72]. [Pg.306]

Dichloroacetic acid is produced in the laboratory by the reaction of chloral hydrate [302-17-0] with sodium cyanide (31). It has been manufactured by the chlorination of acetic and chloroacetic acids (32), reduction of trichloroacetic acid (33), hydrolysis of pentachloroethane [76-01-7] (34), and hydrolysis of dichloroacetyl chloride. Due to similar boiling points, the separation of dichloroacetic acid from chloroacetic acid is not practical by conventional distillation. However, this separation has been accompHshed by the addition of a eotropeforming hydrocarbons such as bromoben2ene (35) or by distillation of the methyl or ethyl ester. [Pg.89]


See other pages where Acetic acid esters, hydrolysis is mentioned: [Pg.818]    [Pg.818]    [Pg.405]    [Pg.485]    [Pg.561]    [Pg.424]    [Pg.148]    [Pg.424]    [Pg.414]    [Pg.160]    [Pg.1338]    [Pg.16]    [Pg.14]    [Pg.128]    [Pg.62]    [Pg.273]    [Pg.357]    [Pg.99]    [Pg.275]    [Pg.163]   
See also in sourсe #XX -- [ Pg.387 , Pg.388 ]




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