A Rifampicin

Bjerrum et al. (2005) reported the results of an experiment involving broilers infected with a rifampicin-resistant Salmonella typhimurium strain at 15 days of age. Lower numbers of the organism were found in the gizzard and ileum of birds receiving whole wheat compared with pellet-fed birds. 

Bouche, J.-P., Zechel, K., Komberg, A. DNA G gene product, a rifampicin resistant RNA polymerase, initiates the conversion of a single-stranded coliphage DNA to its duplex replicative form. J. Biol. Chem. 250, 5995 (1975)... 

Reimers D, Jezek A. Rifampicin und andere Antituberkulohka bei gleichzeitiger oraler Kontrazeption. [The simultaneous use of rifampicin and other antitubercular agents with oral contraceptives.] Prax Pneumol 1971 25(5) 255-62. 

There is no evidence that rifampicin causes clinically significant deleterious effects on the immune system in humans (78), whereas it can cause immunosuppression in animals (79). Rifampicin partially suppresses cutaneous hypersensitivity to tuberculin and T cell function (80). In 33 patients with leprosy treated with a rifampicin drug combination, a flu-like illness or antibodies to rifampicin-conjugated proteins were not observed (81). 

Buniva G, Palminteri R, Berti M. Kinetics of a rifampicin-trimethoprim combination. Int J Chn Pharmacol... 

Treiber, A., Schneiter, R., Hausler, S. and Stieger, B. (2007) Bosentan is a substrate of human OATP1B1 and OATP1B3 inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metabolism and Disposition The Biological Fate of Chemicals, 35, 1400-1407. 

Rifampicin must bind to the (3 subunit of RNA polymerase to inhibit the enzyme. A mutation in the gene encoding this subunit that would interfere with the binding of the antibiotic but not with polymerization would produce a rifampicin-resistant cell. 

Schierholz JM, Nagelschmidt K, Nagelschmidt M, et al. Antimicrobial central venous catheters in oncology efficacy of a rifampicin-miconazole-releasing catheter. Anticancer Res April 2010 30(4) 1353-8. 

Rabussay, D., Zillig, W. A rifampicin resistant RNA-polymerase from E. coli altered in the j5-subunit. FEBS Letters 5, 104-106 (1969). 

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