Rifampicin/miconazole

Schierholz JM, Nagelschmidt K, Nagelschmidt M, et al. Antimicrobial central venous catheters in oncology efficacy of a rifampicin-miconazole-releasing catheter. Anticancer Res April 2010 30(4) 1353-8. 

Lorente L, Lecuona M, Ramos MJ, et al. The use of rifampicin-miconazole-impregnated catheters reduces the incidence of femoral and jugular catheter-related bacteremia. Clin Infect Dis November 2008 47(9) 1171-5. 

Antimicrobials. Aztreonam, cefamandole, chloramphenicol, ciprofloxacin, co-trimoxazole, erythromycin, fluconazole, itraconazole, ketoconazole, metronidazole, miconazole, ofloxacin and sulphonamides (including co-trimoxazole) increase anticoagulant effect by mechanisms that include interference with warfarin or vitamin K metabolism. Rifampicin and griseofulvin accelerate warfarin metabolism (enzyme induction) and reduce its effect. Intensive broad-spectrum antimicrobials, e.g. eradication regimens for Helicobacter pylori (see p. 630), may increase sensitivity to warfarin by reducing the intestinal flora that produce vitamin K. 

Yucel N, Lefering R, Maegele M, et al. Reduced colonization and infection with miconazole-rifampicin modified central venous catheters a randomized controlled clinical trial. J Antimicrob Chemother December 2004 54(6) 1109-15. 

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