A-methyl-D-aspartic acid

ATP, adenosine 5 -triphosphate BH4, 5,6,7,8-tetrahydrobiopterin BMPO, 5- er -butoxycarbonyl-5-pyrroline A-oxide DBNBS, 3,5-dibromo-4-nitrosoben-zene sulfonate DEPMPO, 5-diethoxyphosphoryl-5-methyl-l-pyrroline A-ox-ide DMPO, 5,5-dimethyl- 1-pyrroline A-oxide EMPO, 5-ethoxycarbonyl-5-methyl-l-pyrroline A-oxide GSH, glutathione (y-L-glutamyl-L-cysteinyl-glycine) HRP, horseradish peroxidase MNP, 2-methyl-2-nitrosopropane MPO, myeloperoxidase NAD(P)H, fl-nicotinamine adenine dinucleotide (3 -phosphate), reduced from NMDA, A-methyl-D-aspartic acid PBN, N-tert-butyl-a-phenylnitrone PMN, polymorphonuclear lymphocyte POBN, a-(4-pyridyl-l-oxide)-A-fer -butylnitrone SOD, superoxide dismutase TEMP,... 

Djebaili M., De Bock F., Bailie V., Bockaert J., and Rondouin G. (2002). Implication of p53 and caspase-3 in kainic acid but not in A-methyl-d-aspartic acid-induced apoptosis in organotypic hippocampal mouse cultures. Neurosci. Lett. 327 1 1. 

Bigge, C.F., Drummond, J.T., Johnson, G., Malone, T., Probert, A.W., Jr., Marcoux, F.W., Coughenour, L.L., and Brahce, L.J., Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoaIkanoic acids as competitive A-methyl-D-aspartic acid antagonists, J. Med. Chem., 32, 1580, 1989. 

Sofroniew, M.V. and Pearson, R.C.A, (1985). Degeneration of cholinergic neurons in the basal nucleus following kainic or A-methyl-D-aspartic acid application to the cerebral cortex in the rat. Brain Res. 339 186-190. 

Glover, R. T, Angiolieri, M., Kelly, S., Monaghan, D. T, Wang, J. Y, Smithgall, T. E., and Buller, A. L. (2000). Interaction of the A-methyl-D-aspartic acid receptor NR2D suhunit with the c-Abl tyrosine kinase./. Biol. Chem. 275, 12725-12729. 

Spirolides B and D were shown to have no effect on A-methyl-D-aspartic acid (NMDA), a-amino-... 

Compounds that have agonistic properties at glutamate or aspartate receptors are also CNS stimulants, readily cause convulsions, and presumably could also be employed as analeptics. Three separate excitatory amino acid receptor subtypes have been characterized pharmacologically, based on the relative potency of synthetic agonists. These three receptors are named for their respective prototypical agonists A/-methyl-D-aspartate [6384-92-5]... 

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. 

NMDA (iV-methyl-D-aspartic acid) is a synthetic derivative of aspartic acid and represents the prototypical agonist at the NMDA receptors for which the latter were named. 

Jacocks, H.M. and Cox, B.K., Serotonin-stimulated [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine, J. Pharmacol. Exp. Ther., 262, 356, 1992. 

Trujillo K., Akil H. Excitatory amino acids and drugs of abuse a role for A-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence. Drug Alcohol Depend. 38 139, 1995. 

The main building block of PEDC (1 -phenyl-2-[(S)-l-aminoethyl] -N,N -di-ethylcyclopropanecarboxamide), a potent NDMA (N -methyl-D-aspartic acid) receptor antagonist of a cyclopropane structure, N -benzyl-C-cyclopropyl nitrone... 

The dialkoxyphosphinydifluoromethyllithium reagent has also been used in the preparation of bioactive compounds such as 2-amino-7,7-difluoro-7-phos-phonoheptanoic acid for evaluation in the -methyl-D-aspartic acid binding assay [265], 9-(5,5-difluoro-5-phosphonopentyl)quanine as a multisubstrate analog inhibitor of purine nucleoside phosphorylase [266], fluorinated phosphoserine analog [267, 268] (Scheme 91) and nucleoside 5 -deoxy-5 -di-fluoromethylphosphonates [267,269] (Scheme 92). 

Ahmed, M . S., Mather, A., Enna, S. J. Binding of pHJdesglycinyl remacemide to rat brain membranes association with the benzomorphan attachment site of the N-methyl-D-aspartic acid receptor channel, Brain Res. 1999, 8, 46-50. 

Eide, P. K., Jorum, E., Stubhaug, A., Bremmes, J., Breivik, H. Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine a double-blind, cross-over comparison with morphine and placebo, Pain 1994, 58, 347-354. 

Salituro, F. G., Harrison, B. L., Baron, B. M., Nyce, P. L., Stewart, K. T., Kehne, J. H., White, H. S., McDonald, I. A. 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site, J. Med. Chem. 1992, 35, 1791-1799. 

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