A,co-diaminoalkanes

In the conversion of 3,4,5,6-tetrabromo-l,2-bis(bromomethyl)benzene into the tetrabromoisoindole (Scheme 5.4), the bisalkylation of the primary amine in the First step of the reaction is promoted by the addition of benzyltrimethylammonium methoxide [22]. 2-Chloromethylpyridine reacts with a series of a,co-diaminoalkanes, as well as 1,2-diaminobenzene, to produce Af V -dialkylated and N,N,N N -tctra-alkylated products [23]. 

Halogen-substituted T,2, 3, 4 -tetrahydro-l-naphthyl-1,4,5,6-tetrahydropyri-midines, such as (XCVll), and their non-toxic water-soluble salts, are useful as hypotensive agents [681] 2-(p-Aminophenyl)-l,4,5,6-tetrahydropyrimidines (XCVlll), prepared from p-aminobenzoic acid ester and a,co-diaminoalkanes, are active as local anaesthetics over a wide pH range [682]. 

Similarly, the reaction of pyrazaboles with a,co-diaminoalkanes proceeds with symmetrical cleavage of the pyrazabole skeleton. This latter process was used for the synthesis of monomeric pyrazol-l-ylboranes (see Sect. III. A). 

Fig. 6 Binding free energies -AG° as a function of the lengths of the hydrophobic binding sites, quantified by the number of methylene groups n(CH2), for (filled circle) bola-amphiphiles, a, co-diaminoalkanes, and (open circle) poly-bolaamphiphiles, poly(imino-oligomethylene)s at pH 6.7 and 25°C, determined by ITC [119]...

A new class of diamine spacer was synthesised from a,co-diaminoalkanes and 4-nitrophthalic anhydride the resulting a, -bis(4-aminophthalimido)alkanes were polycondensed with one of the following acid chlorides terephthaloylchlo-ride, 2-phenylthioterephthaloylchloride, naphthalene-2,6-dicarboxylic acid or 4,4 -biphenyldicarboxylic acid chloride [40]. Thermotropic behaviour was con-... 

Constrained a,co-Diaminoalkanes connecting Disruption of the hexameric gp41 core Micromolar IC50 values achieved in [86]... 

The reaction between ammonia (or a primary or secondary amine), formaldehyde and phosphorous acid is only one particular case of the Kabachnik-Medved -Fields reaction, consisting of the aminomethylation of a phosphorus species possessing a reactive P(0)H group, and so is of the Mannich type. The involvement of ammonia leads only to 226 and the intermediate aminomethylphosphonic 227 (R = H) and aminobis(methylene)bisphos-phonic acid 228 (R = H) are not isolable although they are detectable by NMR spectroscopy the sequence can be stopped at the earlier stages if a primary or secondary amine is used The use of a,co-diaminoalkanes leads to complexones of type 229 . Ethanolamine affords the related bis(phosphonic acid) 230 and diethanolamine yields 231 under similar conditions acidolysis of the linear compounds brings about their cyclization... 

The ideal of cascade synthesis was first introduced in 1978 by Vogtle [41] etal., who reported reactions involving Michael additions of an amine to acrylonitrile, followed by reduction of the nitrile group to an amino group. In 1979 [40] a Dow research group reported that a variety of amines could be added to methyl acrylate and the products subsequently amidated with a, co-diaminoalkane to give cascade products . Further work by the Dow group has expanded this area to produce the Starburst system [40]. An in depth review by Tomalia [40] et al. should be consulted. 

A number of poly(esterimide)s (41) have been shown to exhibit mesophase behaviour. The products of the reaction between trimellitic anhydride and a,co-diaminoalkanes containing from 4 to 12 methylene units and containing various 4,4 aromatic entities crystallize in a layered morphology but show certain smectic properties. The polymer with Ar = 4,4 -biphenylyl melts into a smectic mesophase. The melting point varies from 297 °C for the polymer with n= 12 to 393 °C for the polymer with = 4. The liquid crystalline phase becomes an isotropic liquid at 386 °C for the polymer with = 12 and at 467 °C for the polymer with = 4. The rate of crystallization of all these polymers is usually fast with the exception of the polymers based on Ar= 1,4-phenylene, 1,4-tetrachlorophenylene and 2,6-naphthalene that exhibit smectic mesophases the other polymers melt directly into an isotropic phase. 

Shi T, Zhao J, Shoeib T, Siu KWM, Hopkinson AC. Fragmentation of singly charged silver/ a,co-diaminoalkane complexes competition between the loss of Hj and AgH molecules. Eur J Mass Spectrom. 2004 10 931-40. 

However, polyalkylenimides can be prepared from pyromellitic anhydride and oc,co-diaminoalkanes in solution of NMP. NMP seems to provide a much more convenient medium for these reaction than other organic solvents, and in this way, high molecular weight poly(amic acid)s and polyimides have been attained [63,64],... 

Since the cyclic ureas can be obtained from 1,2-diaminoalkanes and CO 2. this reaction represents a potentially useful method for the industrial production of diisocyanates. In contrast, a cyclic chloroformamidinium chloride is obtained from 1,3-dimethyl-... 

Kricheldorf has reported the synthesis of lyotropic poly(amide-imide)s and poly(benzoxazole-amide)s. These were prepared by the polycondensation of N,N-bis(trimethylsilyl)-p-phenylenediamine or N,AT -bis(trimethylsilyl)-3,3 -dim-ethylbenzidine with the diacyl chloride of trimellitimide of p-aminobenzoic acid, or the imide formed from p-amino benzoic acid and terephthalic acid. Lyotropic behaviour was observed in cone, sulphuric acid solution [38]. A series of thermotropic poly(imide-amide)s was prepared based on trimellitimides formed from trimellitic anhydride and an a, -bis(4-aminophenoxy) alkane with carbon chain lengths 9-12. Melting points were in the range 250-300 °C. They formed smectic A phases and tended to degrade around the isotropisation temperatures (around 350 °C). Pendant methyl groups or occupied meta- groups tended to prevent mesophase formation [39]. Novel LC poly(imide-amides) have also been synthesised from new diamine spacers derived from linear diaminoalkanes and 4-nitrophthalic anhydride. A smectic and nematic phase were observed when 4,4 -biphenyl dicarboxylic acid was used as co-monomer [40]. 

Li and co-workers synthesized H5.28 by a CuAAC reaction between a pil-lar[5]arene containing 10 allqme moieties and phenyl azide (Figure 5.27). The K values of the complexes between five diaminoalkane guests and H5.28 were all in the vicinity of 10 (Table 5.7, runs 125-129), which is much larger than that observed for per-methylated pillar[5]arene... 

Some of the important systems such as Cu Il-acetylacetonate in di-methylsulfoxide for polymerization of methyl methacrylate [39], Cu Il-chi-tosan for methyl methacrylate and aaylonitrile polymerization [40], Cu II-(vinylamino-vinylacetamide) copolymer [41], Cu II-(a,a)-diaminoalkane) [42], and Cu II—imidazole [43] for acrylonitrile polymerization, and Cu II— amine in CQ4 for acrylonitrile and methyl methacrylate polymerization [44], Mn Ill-acetylacetonate for vinyl chloride polymerization [45], Mn HI, Co III, and Fe Ill-acetylacetonate for methyl methacrylate polymerization... 

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