Zuclopenthixol

Across the sites, an average of 15% of inpatients received depot antipsychotic drugs (Sim etal, 2004b). This was most common in Singapore (75%) followed by Taiwan (20%), Japan and China (6%). The depot antipsychotic drugs used were fluphenazine decanoate, flupenthixol decanoate, zuclopenthixol decanoate, haloperidol decanoate, pipothiazine palmitate, and fluphenazine enanthate. 

Angelo HR, Petersen A. 2001. Therapeutic drug monitoring of haloperidol, perphenazine, and zuclopenthixol in serum by a fully automated sequential solid phase extraction... 

Jerling, M., Dahl, M.-L., °Aberg-Wistedt, A., Liljenberg, B., Lan-dell, N.-E., Bertilsson, L., and Sjoqvist, F. (1996) The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol. Clin Pharmacol Ther 59 423-428. 

Thioxanthene derivatives flupenthixol decanoate flupenthixol dihydrochloride thiothixene zuclopenthixol acetate zuclopenthixol decanoate zuclopenthixol dihydrochloride... 

Zuclopenthixol is a thioxanthene of high potency with general property similar to the chlorpromazine. It has a piperazine side-chain. 

Common Name Zuclopenthixol hydrochloride Clopixol Cisordinol Structural Formula ... 

XIV) Flupentixol (434.2) C23H25FjN2OS XV) Zuclopenthixol (400.1) C23H25F3N2OS XVI) Chlorprothixene (315.1) XVII) Thiothixene (443.2) Ci8Hi8C1NS CjjH NjOjSj ... 

Weinmann W, Muller C, Vogt S, Frei A (2002) Lc-ms-ms analysis of the neuroleptics clozapine, flupentixol, haloperidol, penfluridol, thioridazine, and zuclopenthixol in hair obtained from psychiatric patients. J Anal Toxicol 26(5) 303-307... 

Fagerlund, B., Mackeprang, T., Gade, A., Glenthoj, B. Y. 2004, Effects of low-dose risperidone and low-dose zuclopenthixol on cognitive functions in first-episode drug-naive schizophrenic patients, CNS.Spectr., vol. 9, no. 5, pp. 364-374. 

Zuclopenthixol, a polysubstituted piperazine-thioxanthene structure, antipsychotic [53772-83-1],... 

Case series and reviews have suggested superior effectiveness of zuclopenthixol acetate in the acute management of disturbed behavior caused by serious mental illness. However, this seems not to have been supported by the evidence from an analysis of randomized controlled trials (88). A meta-analysis of five randomized comparisons of zuclopenthixol acetate with other neuroleptic drugs in patients with considerable behavioral disturbance showed that in all studies there was some improvement in mental state scores (BPRS CGI), but none showed statistically significant differences between zuclopenthixol acetate and standard treatment. In three studies there was more sedation in those who took zuclopenthixol acetate than in those allocated to haloperidol. With regard to adverse effects, the studies were not homogeneous one study showed that people who took zuclopenthixol acetate were more likely to need antiparkinsonian drugs (OR = 6.4 Cl = 1.5,17) other studies did not show any differences in this particular outcome. 

Identical twin brothers, aged 37 years, had both suffered from bipolar disorder since their early twenties and had been treated with chlorpromazine, haloperidol, lithium, and carbamazepine before developing priapism. One of them developed priapism after taking trazodone 400 mg/day, and in the 2 years after the initial episode he suffered recurrent painless erections. Initially they occurred daily and lasted 4-5 hours. During a relapse of mania at age 37, he was given oral zuclopenthixol 40 mg/day. On the tenth day he presented with priapism of 4 days duration, which persisted despite zuclopenthixol withdrawal, needle aspiration, and phenylephrine instillation, but subsided 2 weeks later with conservative management. The... 

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