Zoloft™

Tatig (Bioindustria) Zoloft (Roerig) Zoloft (Pfizer 1991)... 

Sertraline Zoloft No Tablet, concentrate 25-50 50-200 Once daily... 

Approved for use in the U.S. in the early 1990s, Sertraline (Zoloft ) is the most prescribed drug of its class. In the original synthesis, the carbonyl group of the... 

Plants affecting the serotoninergic neurotransmission are therefore interesting because of their potentials for the treatment of depression, which is the eighth leading cause of death in the United States. It is generally agreed that there is a correlation between diminished serotonin neurotransmission and episodes of major depression, and a number or inhibitors of serotonin-uptake inhibitors are available on the market, such as sertraline (Zoloft ). 

Zoloft (Sertraline) Depression Obsessive-compulsive disorders Panic Post traumatic stress disorder 2.0 0.7 1996 - EU and US Once daily... 

Sertraline (Zoloft, Pfizer) selective serotonin (5-hydroxytryptamine 5HT) uptake inhibitor for treating major depression and obsessive compulsive disorder... 

Sertraline (Zoloft, Pfizer) Central nervous system GPCR... 

Tricyclic drugs have, as the name implies, a three-ring structure, and interfere with reuptake of norepinephrine and/or serotonin into axon terminals. Tricyclic drugs include imipramine (Tofranil), amitriptyline (Elavil), clomipramine (Anafranil), and nortriptyline (Pamelor, Aventil). Tricyclics have the occasional but unfortunate cardiovascular side effects of arrhythmia and postural hypotension. Newer, nontricyclic antidepressants have been developed that are collectively referred to as SSRIs. These have a potent and selective action on serotonin, and lack the cardiovascular side effects of the tricyclics. These include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), and fluvoxamine (Luvox). A fifth SSRI, citalopram (Celexa) has been used in Europe and has recently been approved in the United States. Venlafaxine (Effexor) blocks reuptake of norepinephrine and serotonin, while bupropion (Wellbutrin) acts on both dopamine and norepinephrine. 

Pfizer has implemented a substitution for a range of hazardous solvents (methylene chloride, tetrahydrofuran, toluene, and hexane) in its formulation of Zoloft - the most... 

A breakthrough in the treatment of major depression was the discovery of fluoxetine, marketed as Prozac. Fluoxetine has a mechanism of action similar to that of imipramine with an important exception. It is a selective serotonin reuptake inhibitor, an SSRI. This strongly suggests that, in some sense, the symptoms of major depression result from a deficit in serotonin specifically. By inhibiting its reuptake from the synapse, the activity of serotonin is enhanced. Two other important drugs for major depression, sertraline (Zoloft) and paroxetine (Paxil), among several others,... 

The current SSRIs in the United States inclnde fluoxetine, fluvoxamine, sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro). All effectively treat major depression. In addition, one or more of the SSRIs has been shown effective in the treatment of dysthymic disorder, the depressive phase of bipolar disorder, premenstrual dysphoric disorder, panic disorder, social phobia, obsessive-compnlsive disorder, bnlimia nervosa, and binge-eating disorder. 

Sertraline (Zoloft). Sertraline was the second SSRI released in the United States and is approved for the treatment of major depression and many anxiety disorders. It should be started at 25-50 mg/day and increased to lOOmg/day over the first 10-14 days. Many patients require doses nearing 150 mg/day for full benefit. The side effects of sertraline are comparable to other SSRIs. 

Other Antidepressants. Antidepressant refinements for the next 30 years primarily consisted of the development of new TCAs. However, in 1988, a novel antidepressant class, the selective serotonin reuptake inhibitors (SSRIs), was introduced in the United States. The chief innovation of the SSRIs was that they afforded the comparable effectiveness of the TCAs with fewer side effects and minimal toxicity. The debut of the SSRIs coincided with the reworking of the nosology of the anxiety disorders in DSM-III and DSM-IV. As a result, the SSRIs have been studied extensively in each of the respective anxiety disorders and in many cases have obtained FDA approval for the treatment of one or more of these anxiety syndromes. The SSRIs currently available in the United States include citalopram (Celexa), escitalo-pram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft). 

Newer Generation Antidepressants. All SSRIs have been shown effective in the treatment of panic disorder. Of these, flnoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), as well as the SNRI venlafaxine ER (Effexor XR), have received FDA approval for the treatment of panic disorder. Because they are safer and easier to tolerate, SSRls/SNRls have largely supplanted the MAOIs and TCAs as standard treatments (along with benzodiazepines) for panic disorder. 

The TCAs were once widely used to treat depression in brain-injured patients, but they have been replaced as first-line treatments by the so-called selective serotonin reuptake inhibitors (SSRIs) including citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), and, most recently. 

Zinacef 22 Zithromax 17 Zocor 61 Zofran 53 Zdmitriptan 69 Zoloft 61 Zolpidem 69 Zomig 69 Zostrix 21 Zosyn 84 Zovirax 12 Zyban 19 Zyflo 69 Zyloprim 14 Zyprexa 53 Zyrtec 23... 

The brand-name drug products included in the study represent some of the largest drug products as measured by annual sales. They include blockbuster drugs such as Capoten, Cardizem CD, Cipro, Claritin, Lupron, Neurontin, Paxil, Pepcid, Pravachol, Prilosec, Procardia XL, Prozac, Vasotec, Xanax, Zantac, Zocor, Zoloft, and... 

Prilosec, Procardia XL, Prozac, Vasotec, Xanax, Zantac, Zocor, Zoloft, and Zyprexa. 

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