Zoloft - Sertraline hydrochloride

Zoloft (Sertraline hydrochloride). Pfizer Inc. US Prescribing infcnnation, June 2007. 

ZOLOFT oral concentrate is available in a multidose 60-mL bottle. Each milliliter of solution contains sertraline hydrochloride equivalent to 20 mg of sertraline. The solu-... 

USAN Sertraline Hydrochloride Trade Name Zoloft ... 

The most widely known SSRIs are fluoxetine hydrochloride (4, Prozac , Lilly), sertraline hydrochloride (5, Zoloft , Pfizer) and paroxetine hydrochloride (6, Paxil , GSK). Fluoxetine (4, Prozac ) was the first SSRl approved and effected a revolutionary change in the treatment of depression. In 2000, it was the most widely prescribed antidepressant drug in the United States with worldwide sales of 2.58B. Sertraline (5, Zoloft ) has been available in the United States since 1992 and had worldwide sales of 2.14B in 2000. Compared to fluoxetine (4), it has a shorter duration of action and fewer CNS activating side-effects such as nervousness and anxiety. Paroxetine (6, Paxil ) generated worldwide sales of 2.35B in 2000 and has a relatively benign side-effect profile, which favors its use with elderly patients. 

Atruline Cp-51974-1 Gladem Lustral Serad Sertraline hydrochloride Tatig Tresleen Zoloft. Serotonin uptake inhibitor. Antidepressant. Crystals mp = 243-245 [aj8 38 (c 2 MeOH). Pfizer Inc. Roerig Div. Pfizer Pharm. 

Other SSRIs include paroxetine hydrochloride (Paxil , Glaxo SmithK-line), fluoxamine maleate (Luvox , Abbott), sertraline hydrochloride (Zoloft , Pfizer), vilazodone hydrochloride (Viibryd , Eorest Laboratories), and citalopram hydrobromide (Celexa , Eorest Laboratories). 

Sertraline hydrochloride was introduced to the market by Pfizer and known under the brand names Zoloft and Lustral. Sertraline is an antidepressant " " of the selective serotonin reuptake inhibitor (SSRI) class and is primarily used to treat major depression, highly effective for the treatment of panic and social anxiety disorders. ... 

Sertraline hydrochloride (known under the trade names Zoloft and Lustral, both from Pfizer) is an antidepressant chiral drug acting as a selective serotonin reuptake inhibitor (SSRI). It is primarily used in major depression treatment and as obsessive/compulsive, panic, and social anxiety disorders. Ir-Catalyzed enantioselective hydrogenation of C=N bond can be employed to install a second stereogenic... 

Sertraline (cis-(lS)-N-methyl-4-(3,4-dichlorophenyl)-l,2,3,4-tetrahydro-l-naphtha-leneamine) in the hydrochloride salt is an antidepressant marketed as Zoloft . U.S. 4,536,518 (to Pfizer, Inc.) describes the preparation of the API. Estimate the cost of production of the APL... 

Caruso, F., A. Besmer, and M. Rossi, The absolute configuration of sertraline (Zoloft) hydrochloride, Acta Crystallograph.C Crystal Struct. Commun. C55 (10) 1712-1714 (1999). 

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