Sphingolipids inositol-containing

Lester, R.L. and K. Kaul Isolation and characterization of the inositol containing sphingolipids of tobacco and the development of relatively selective methods for the removal of these constituents from tobacco Proc. Univ. KY Tobacco Health Workshop Conf. (1973) 777-786. Levasseur, G., J. Filion, and M.J. Kaiserman Less hazardous Fact or fiction The Canadian experience 61st Tobacco Science Research Conference, Program Booklet and Abstracts, Vol. 61, Paper No. 19, 2007,... 

Sphingolipids such as cerebrosides and ceramides are minor but widely distributed constituents of fungi. Certain species contain characteristic sphingosine-containing lipids such as the inositol-containing phosphorylceramides of S. cerevisiae (cf. Weete, 1980). Other minor Upids include hydrocarbons while sterols (and sometimes carotenoids) are often major components. A full description of such lipids is outside the remit of this section and, for further details, the reader is directed to Weete (1980), Brennan etal. (1974) and Goodwin (1973). 

Fig. 2. General structural features of fluorescent and spin-labeled lipid analogs. The fluorescent lipids usually contain a short-chain fatty acid, amino-caproic acid, that is derivatized with 4-nitrobenzo-2-oxa-1,3-diazole (NBD), or valeric acid that is derivatized with a boron dipyrromethene difluoride (BODIPY) moiety. For fluorescent phospholipids, X can be hydrogen or the esterified forms of choline, ethanolamine, serine, or inositol. R>r fluorescent sphingolipids, Y can be hydrogen or the esterified fonns of phosphocholine or mono- or oligosaccharides typical of glycosphingolipids. The spin-labeled lipids modified in the fatty acid portion contain a 4-doxylpentanoyl fatty acid in the sn-2 position. Those modified in the polar head group contain a tempocholine moiety in place of choline. The X substituent for the acyl spin-labeled lipids can be hydrogen or the esterified forms of choline, ethanolamine, or serine.

Lester and co-workers have studied a family of sphingolipids which also contain inositol and phosphate (Lester et al., 1974). These compounds have... 

Yeast sphingolipids contain inositol rather than choline, as is the case for sphingomyelin in mammalian cells [34],... 

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