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Ketosphinganine reductase

A protein that would be a logical interaction partner for SPT is 3-ketosphinganine reductase, which catalyzes the next step of the sphingolipid biosynthetic pathway. The gene for this reductase has been identified in yeast (T. Beeler, 1998) and in mammals (FVTl) (A. Kihara, 2004), and the sequence has coil-coil motifs that might interact with a similar motifs on SPT. [Pg.377]

Ketosphinganine-Reductase (NADPH) / NH2 HO. A /. (CH2)i2CH3 OH D-eiyfliro-Sphinganine Sphinganine- /V-Acyltransferase H3C(CH2)ieCO-SCoA... [Pg.179]

FIGURE 3.10 Biosynthetic pathway of ceramide. SPT, serine palmitoyltransferase 3-KSR, 3-ketosphinganine reductase Cer-Synthase, ceramide synthase. In fact, the reaction catalyzed by ceramide synthase leads to dihydroceramide. Ceramide is obtained by the secondary action of a desaturase that creates a trans double bond between carbons C4 and C5 of the sphingosine moiety (A). [Pg.63]

See other pages where Ketosphinganine reductase is mentioned: [Pg.1767]    [Pg.91]    [Pg.379]    [Pg.1046]    [Pg.455]    [Pg.62]    [Pg.1767]    [Pg.1673]    [Pg.91]    [Pg.379]    [Pg.1046]    [Pg.455]    [Pg.62]    [Pg.826]    [Pg.293]    [Pg.293]    [Pg.1768]   
See also in sourсe #XX -- [ Pg.403 ]



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Ketosphinganine

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