Xylene, exposion properties

The irritancy properties of isophorone have also been observed in humans exposed occupationally to isophorone. In an industrial hygiene survey, Kominsky (1981) reported that the eye and nose irritation complained of by a screen printer could have been caused by 4-minute exposure to 25.7 ppm isophorone, which was measured in the personal breathing zone while the worker was washing a screen. Lee and Frederick (1981) found that eye, respiratory, and skin irritation were among the complaints of 27/35 workers in a printing plant where isophorone and other solvents (xylene, methylene chloride, and toluene) were used. On the day of measurement, two of the screen printers were found to be exposed to 8-hour TWA concentrations of isophorone of 0.7 and 14 ppm, but it was not clear whether these two individuals were among the workers complaining of irritation. The odor threshold for isophorone in air has been reported to be 0.2 ppm (v/v) (Amoore and Hautala 1983). 

Properties Coloriess liq. or pale yel. cryst. sol. in most org. soivs. misc. with acetone, benzene, chlorofomt, dioxane, ethyl acetate, ethanol, xylene insol. in water m.w. 243.24 dens. 1.1133 (30 C) vapor pressure 1 mm (100 C) m.p. 27 C b.p. 120 C (5 mm) flash pt. > 176 F Toxicology LD50 (oral, rat) 590 mg/kg, (IV, mouse) 180 mg/kg poison by IV route toxic by ing. and inh. harmful solid TSCA listed Precaution Flamm. exposed to heat, flame, or oxidizers avoid contact with acid... 

Empirical CsHnNO Formula C6H5NHCH2CH2OH Properties Pale yel. crystals si. sol. in water si. sol. in hot xylene m.w. 137.20 dens. 1.085 vapor pressure 0.002207 mm Hg m.p. 56-57 C b.p. 157-160 C (17 mm) ref. index 1.5790 Toxicology LD50 (oral, rat) 2230 mg/kg, (skin, rabbit) 63 mg/kg poison by IP, IV routes, skin contact mod. toxic by ing., subcut. and other routes readily absorbed thru skin skin and severe eye irritant TSCA listed Precaution Combustible exposed to heat or flame... 

The topical application of the EO of Myrica esculenta Buch. Ham. Ex D. Don. (Myricaceae) exhibited strong suppression of mouse ear edema, induced by xylene. The anti-in ammatory activ ity of the EO was found to be 85.3% at topical application. Diclofenac exposed 87.5% of inhibition, which is somewhat more than for the EO. Nevertheless M. esculenta EO showed potent anti in ammatory properties (Agnihotri et al., 2012). 

Organophosphates, thiocarbamates, carbamates, carbamoyloximes, dithiocarbamates, and ureas were included among 100 pesticides and metabolites detected on TLC plates by their cholinesterase inhibiting properties. After developing the plates in ether, xylene, di-n-butyl ether, n-butyl acetate or methyl-isobutyl ketone, the plates were exposed to bromine vapor. The compounds were oxidized to their oxo derivatives, which exhibited more effective cholinesterase inhibitory activity. Bovine liver suspension served as enzyme source and the substrates 2-naphthyl acetate and Fast Blue B salt as the chromogenic agents (163a). 

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