Xylan sulphates

Xylan sulphates, known also as pentosan polysulphates (PPS), are permanently studied with regard to their biological activities [3,419-422]. Usually, sulphuric acid, sulphur trioxide, or chlorsulphonic acid are employed as sul-phating agents alone or in combination with alcohols, amines or chlorinated hydrocarbons as reaction media [423]. 

Sodium xylan polysulphate, an artificially sulphated (1 4)- 3-D-xylan, has been shown to prolong the partial thromboplastin clotting time of plasma. The differential effects of xylan sulphate on different blood serine proteases were discussed in terms of the antithrombin Ill-mediated anticoagulant activity of heparin. 

Yllner, S., and Enstrom, B. (1956). Studies of the adsorption of xylan on cellulose fibres during the sulphate cook, Part 1. Sven. Papperstidn. 59, 229-232. 

The close association of histamine and heparin release in anaphylactic shock and in peptone shock suggests that complexes of histamine and heparin are held in biological systems. Histamine binds heparin in vitro, as shown by displacement tests, by dialysis, and by paper chromatography . Dextran sulphate, polymannuronic acid sulphate, polysulphated xylan and the iV-succinyl derivative of de-W-sulphated heparin give compounds with... 

Philipp, B. Nehls, I. Wagenknecht, W. C-N.M.R. spectroscopic study of the homogeneous sulphation of cellulose and xylan in the N2O4-DMF system. Carbohydr. Res. 1987,164,107-116. 

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