Wound articular cartilage

Osteoarthritis is the most prevalent disorder of the skeletal system and as many as 36 million Americans suffer from some forms of arthritis. Cartilage damage from sport injure is also common. Articular cartilage has a limited capacity for repair after injure because it contains no vascular supply and articular chondtrocytes entrapped in dense ECM have limited mobility and low capability of contributing wound healing process (78-79). 

Fibrin is always used as carrier for cells and in conjunction with other scaffold materials. It is completely degradable and injectable, but it has the disadvantage of poor mechanical strength for articular cartilage tissue engineering applications [15]. Bioseed is a fibrin-based product obtained by mixing keratinocytes with fibrin and is used to treat chronic wounds. The matrix properties can be optimized for each different cell type and it is a unique feature of fibrin-based cell carriers [422]. 

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