Wild-type vesicular stomatitis virus

Similar findings have been observed with retroviral vectors bearing different envelopes. Wild-type vesicular stomatitis virus (VSV) preferentially infects polarized MDCK cells, a model for polarized airway epithelia, across the basolat-... 

The oncolytic viruses include adenovirus, measles, reovirus, vesicular stomatitis virus (VSV),HSV,poxvirus, and vaccinia. Specific examples include (1) ONYX-015, which is an adenoviral oncolytic virus, administered to patients with liver metastases of colorectal cancer and pancreatic cancer [29], (2) Reolysin, which is an oncolytic reovirus administered to patients with glioma [30], and (3) MV-CEA, which is an oncolytic measles virus expressing carcinoembryonic antigen, administered to patients with ovarian cancer [31]. Some oncolytic viruses are wild type and are apparently not pathogenic in humans, such as the Newcastle disease virus (NDV), which is an RNA avian paramyxovirus. PV701, a naturally attenuated, replication-competent strain of NDV, has been administered to patients with advanced solid tumors [32], The applicability of oncolytic viruses as a therapy for clinical oncology trials is due to their potential selectivity the ability to kill tumor cells but not normal cells. However, the level of attenuation of viral replication in normal cells is limited for most oncolytic vectors. 

Marvaldi, J., and Lucas-Lenard, J., 1977, Differences in the ribosomal protein gel profile after infection of L cells with wild-type or temperature-sensitive mutants of vesicular stomatitis virus. Biochemistry 16 4320. 

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