Water pills preparation

Lakes are prepared by adsorption or precipitation of a soluble dye on an insoluble substrate (e.g., alumina). They are useful in fatty products that have insufficient moisture to dissolve dyes (coated tablets, cake mixes, hard candies, chewing gum). Lakes are insoluble in most solvents including water, have high opacity, are easily incorporated in dry media, and show higher stability to light and heat. They are effective colorants for candies, pills, fats, and oils. The main characteristics and differences between lakes and dyes are well documented. ... 

A low dosage of progestin ( mini-pill ) is used, in the form of medroxyprogesterone acetate, which is active at a very low dose. The mini-pill does not inhibit ovulation, but rather interferes with the endometrium and the cervical mucus. The use of this pill prevents most of the side effects of oral contraception, specifically nausea, water retention, and in some cases thrombophlebitis. However, a lower success rate and other frequent side effects have reduced the widespread acceptance of this preparation. Nevertheless, the mini-pill has a role to play in certain specific situations. For example, in an uncommon form of epilepsy called catamenial epilepsy, female patients will experience seizures at particular times during their menstrual cycle, reflecting the fact that seizure focus is stimulated by estrogens but inhibited by progestins. In such women, the mini-pill may afford not only birth control but also improved seizure control. 

Method of preparation administration Grind the above medicinals into fine powder and make into pills with honey weighing 3g apiece. Take 1 pill 2-3 times per day with warm water. Children should be given half the adult dose. If the patient is unconscious, the medicine may be administered by nasogastric tube. 

Since some of these medications were given orally, solid dosage forms were already prepared early in human history by the tribal medicine people, because fine powders can not be swallowed easily and the concoctions often had a bad taste. To that end, the powdered drugs were mixed with binders, for example starch (flour) and water or honey, and rolled into spherical pills. Honey was often also used to mask the taste. Because the pills thus produced were still sticky after rolling, they were sometimes coated, for example with pollen, to render them dry and easily storable. 

Sample preparation Powder tablets or pills. Weigh out an amount of powdered tablets or pills or capsule contents, dissolve in 5 mL EtOH, dilute with 150 mM HCl containing 40 mM sodium dodecyl sulfate. Dilute suspensions or drops with 150 mM HCl containing 40 mM sodium dodecyl sulfate. Filter solutions if necessary. 10 mL Solution in 150 mM HCl containing 40 mM sodium dodecyl sulfate + 1 mL 100 mM sodium nitrite, let stand for 5 min, add 1 mL 300 mM stilfamic acid, let stand for 10 min, add 500 p-L 30 mM N-(l-naphthyl)ethylenediamine dihydrochloride, make up to 25 mL with water, inject an aliquot. 

By random and site-directed mutagenesis, variants of the enzyme have been prepared with improved thermal stability. While the wild-type lipase showed a thermal denaturation temperature (I d) of 61 °C, several of the variants obtained with one or more amino acid substitutions in the vicinity of the N-terminal amino acid had a of 64—66°C. One of the variants showed improved CTR hydrolysis at pH 9 and 75°C, and its temperature optimum was determined at 65°C [1]. The thermostability of the enzyme could be further improved by site-specific mutagenesis using synthetic nucleotides [81], and variants with a of 71-72°C were obtained [101]. The optimized PET hydrolase could be employed for PET fabric treatments performed at 75°C, resulting in a de-pilling effect and improved water absorption. 

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