Water metabolism deficiency

The drugs for treating hypertension can quickly descend the Qi and Yang of Liver, but they may suppress the Liver-Qi. They may also slow down water metabolism and blood circulation. Therefore the syndrome can change into one of Liver-Qi stagnation with Kidney-Yin and Liver-Yin deficiency, or Liver-Qi stagnation with dampness accumulation in the Middle-Jiao. 

Kidney-Yang deficiency is often seen in elderly people, people with a poor constitution and patients with chronic diseases. When the Kidney-Yang fails to accelerate water metabolism, edema or frequent urination may occur. When the Kidney-Yang and Qi are unable to warm the Lower-Jiao and maintain its function, impotence, infertility, dysmenorrhea and aqueous-grainy diarrhea may occur. 

Damp-cold accumulation often coexists in Yang deficiency syndrome. Because cold obstructs the meridians, this leads to obstruction of Qi movement and water circulation, and cold-dampness is thus formed. Moreover, when the Yang is too weak to steam the fluid into Qi and Yin, the water metabolism becomes very slow and the water may accumulate in certain places in the body. In this condition, herbs that are warm in nature and have the function of transforming dampness should be used as assistants in formulas. 

Heaviness of the limbs due to Qi deficiency and obstruction of water metabolism use Huang Qi [Astragali radix) to tonify the Qi and promote... 

In the condition of Spleen-Yang deficiency, Gui Zhi can be used to stimulate water metabolism and accelerate water transforming into Qi, thereby relieving edema and difficult urination due to Yang deficiency. In addition, it can particularly warm the blood, stimulate the Heart and promote blood circulation, and can treat cold hands and feet, cramp of the muscles and pain due to cold in the blood. 

A member of the water-soluble B group of vitamins. It can be obtained from thediet orit can be synthesized endogenouslyfrom nicotinic acid, which is itself derived from tryptophan. Nicotinamide is a constituent of the coenzymes NAD and N ADP which have widespread roles in intermediary metabolism. Deficiency of the vitamins causes pellagra. Patients with Hart-nup s disease can develop a pellagra type condition probably due to insufficient endogenous synthesis of the vitamin from tryptophan. 

INTERRELATIONSHIPS. Sodium, potassium, and chlorine are closely related metabolically. They serve a vital function in controlling osmotic pressures and acid-beise equilibrium and they play important roles in water metabolism. Both sodium and potassium ions occur in the body chiefly in close association with the chloride ion therefore, a sodium or potassium deficiency is rarely found in the absence of a chlorine deficiency. 

Although both estrone and estradiol are available for replacement therapy, they suffer the disadvantage of poor activity on oral administration and short duration of action even when administered parenterally, because of ready metabolic disposition. In order to overcome these deficiencies, there was developed a series of esters of estradiol with long-chain fatty acids. These esters are oil-soluble and correspondingly water-insoluble compounds. 

The same is true of the thiazole acid 40. Although discovered as a growth factor, it is unable to sustain the growth of a thiazole-deficient mutant of E. coli in a liquid medium. It does not decarboxylate in water solution at pH 7. Phosphate 41 (Scheme 17) is also biologically inactive. In any case, if there is only one metabolic route to the thiazole of thiamine, the very structures of 39 and 40 show that they cannot both be intermediates. 

On rare occasions an organic aciduria occurs not because of an enzyme deficiency but from a failure to transport or activate a water-soluble vitamin that serves as a cofactor for the reaction in question. Thus, congenital deficiencies in the metabolism of vitamin B12 commonly give rise to methylmalonic aciduria (Fig. 40-1, Table 40-2). Similarly, deficiencies of biotin metabolism can cause a severe organic aciduria (Table 40-2). It is very important to be aware of the defects of vitamin metabolism because the administration of large doses of these cofactors may completely prevent brain damage. 

Depth profiles from the eastern tropical North Pacific (Figure 24.8) show the effects of nitrogen metabolism under 02-deficient conditions. The thermocline is characterized by a sharp decline in O2 concentrations that coincides with increasing nitrate and phosphate concentrations. The oxycline is produced by the respiration of sinking POM under vertically stagnant conditions. Below the oxycline, in depths where O2 concentrations are suboxic, phosphate concentrations continue to increase, but at a slower rate. In contrast, nitrate concentrations decline and reach a mid-water minimum that coincides with a nitrite maximum. The latter is referred to as the secondary nitrite maximum. (At this site the primary nitrite maximum is located at 50 m.)... 

A third mechanism by which the structural bonds between Fe atoms in iron oxides may be weakened involves reduction of structural Fe to Fe". In natural environments, reductive dissolution is by far the most important dissolution mechanism. It is mediated both biotically and abiotically. The most important electron donors, particularly in near surface ecosystems result from metabolic oxidation of organic compounds under O2 deficient conditions. In anaerobic systems, therefore, the availability of Fe oxides i. e. the electron sink, may control the degradation of dead biomass and organic pollutants in the ground water zone (see chap. 21). Reductive dissolution is also often applied to the removal of corrosion products from piping in industrial equipment and the bleaching of kaolin. 

In soils, electrons are produced by the metabolic activity of soil biota. These electrons are usually accepted by O2 dissolved in the soil solution which is then replaced by O2 from the soil air. Oxygen may, however, become deficient if all pores are filled with water as in waterlogged or compacted soils. Fe in Fe oxides may then function as an alternative electron acceptor and Fe ions will be formed according to eq. (16.3). The electrons are transferred from the decomposing biomass to the Fe oxide by microbially produced enzymes. Other potential electron acceptors in soils are nitrate, Mn and sulphate. 

Like folate and vitamin C, vitamin B6 (pyroxidine) is water soluble and like folate has several vitamers. Vitamin B6 may be involved in more bodily functions than any other nutrient (Tambasco-Studart et al., 2005), is a cofactor for many enzymes, especially those involved in protein metabolism, and is also a cofactor for folate metabolism. Vitamin B6 has anticancer activity (Theodoratou et al., 2008), is a strong antioxidant (Denslow et al., 2005), is involved in hemoglobin biosynthesis, lipid and glucose metabolism and immune and nervous system function. Possible consequences of deficiency include anemia, impaired immune function, depression, confusion, and dermatitis (Spinneker et al., 2007). Vitamin B6 deficiency is generally not a problem in the developed world, but there could be as yet poorly defined consequences of suboptimal intake particularly for the elderly. 

---