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Vincristine Phenobarbital

VINCA ALKALOIDS - VINBLASTINE, VINCRISTINE 1. ANTIBIOTICS-rifampicin 2. ANTICANCER AND IMMUNOMODULATING DRUGS - dexamethasone 3. ANTIDEPRESSANTS-St John s wort 4. ANTI EPILEPTICS -carbamazepine, phenobarbital, phenytoin 1 of plasma concentrations of vinblastine and vincristine, with risk of inadequate therapeutic response. Reports of 1 AUC by 40% and elimination half life by 35%, and t clearance by 63%, in patients with brain tumours taking vincristine, which could lead to dangerously inadequate therapeutic responses Due to induction of CYP3A4-mediated metabolism Monitor for clinical efficacy, and t dose of vinblastine and vincristine as clinically indicated in the latter case, monitor clinically and radiologically for clinical efficacy in patients with brain tumours and t dose to obtain desired response... [Pg.342]

Clinically important, potentially hazardous interactions with alprazolam, amphotericin B, anisindione, anticoagulants, dicumarol, eplerenone, erythromycin, methadone, midazolam, phenobarbital, phenytoin, ramelteon, sulfonylureas, trabectedin, vinblastine, vincristine, warfarin... [Pg.235]

Noninterfering metabolites, acetaminophen, aspirin, ( clophosphamide, dextropropo -phene, diamorphine, dihydrocodeine, doxorubicin, methotrexate, metoclopramide, morphine, phenobarbital, prednisone, proceu bazine, prochlorperazine, vincristine... [Pg.603]

Simultaneous acetaminophen, aldosterone, allopurinol, amitriplyline, caffeine, calcitriol, cephalothin, chlordiazepoxide, chlorothiazide, corticosterone, cortisone, dexamethasone, diazepam, ephedrine, ethinyl estradiol, furosemide, hydrocortisone, ibuprofen, imipra-mine, indomethacin, mechlorethamine, methylprednisone, metolazone, nandrolone, naproxen, phenacetin, phenobarbital, phen3doin, probenecid, progesterone, propranolol, sulfasalazine, testosterone, theophylline, vincristine... [Pg.1159]

See other pages where Vincristine Phenobarbital is mentioned: [Pg.196]    [Pg.236]    [Pg.236]    [Pg.496]    [Pg.49]    [Pg.60]    [Pg.138]    [Pg.205]    [Pg.228]    [Pg.384]    [Pg.403]    [Pg.460]    [Pg.489]    [Pg.519]    [Pg.622]    [Pg.745]    [Pg.801]    [Pg.842]    [Pg.888]    [Pg.933]    [Pg.1002]    [Pg.1047]    [Pg.1142]    [Pg.1172]    [Pg.1190]    [Pg.1450]    [Pg.1492]    [Pg.236]    [Pg.623]    [Pg.49]    [Pg.60]    [Pg.138]    [Pg.205]    [Pg.228]    [Pg.384]    [Pg.460]    [Pg.489]    [Pg.519]    [Pg.622]    [Pg.745]    [Pg.801]    [Pg.842]   
See also in sourсe #XX -- [ Pg.670 ]



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