Vignettes

The development of tolerance for GHB has been repeatedly described in clinical vignettes and demonstrated in animal models. For example, with repeated... 

Patient encounter vignettes. Distributed throughout each chapter, these case scenarios facilitate critical thinking skills and lend clinical relevance to the scientific foundation provided. 

American Geophysical Union. Venusian vignette. Available online. URL http //www.agu.org/sci soc/venusian.html. Accessed on March 11, 2008. 

Burnley, J. The romance of invention vignettes from the annals of industry and science. London Cassell, 1886. 376p. 

Robert P. Sharp. Vignettes of Clair Patterson. Unpublished manuscript. 

Friedrich Wohler, Berzelius, and Liebig were among those who initially opposed and even ridiculed Dumas s new approach. The distinguished physical chemist and historian of chemistry J. R. Partington has given us the following vignette ... 

After a brief introduction that sets the work described into a broader context, the report focuses on how a molecular understanding can provide explanations of observed biology and lead to therapies for diseases. Each vignette is accompanied by a figure and hypertext links that lead to a series of pages that interactively show how NCBI tools and resources are used in the research process. 

Another piece of information was necessary before one arrives at a periodic table which is close to the modern view. This is the whole number rule which states that the masses of atoms on the 160 scale (i.e. mass of the major isotope of oxygen is 16.00) tend to have close to integer values. This information was provided by W. D. Harkins (vide infra) and F. W. Aston (Historical Vignette 1.2). 

Bigeleisen and Mayer (Historical Vignettes 4.1 and 4.2), recognizing that the term in Equation 4.78 involving isotopic masses would always cancel in the calculation of... 

Historical Vignette 8.2] Earnest O. Lawrence (1901-1958) was bom in 1901 in Canton, SD. He was educated at the Universities of South Dakota and Minnesota, and at Yale (Ph.D. Physics 1925), and was appointed to the faculty of The University of California, Berkeley in 1928. Two years later he became a Full Professor. In 1926 he was appointed Director of the University s Radiation Lab (now the Lawrence Berkeley National Laboratory), a position he held until his death. 

Historical Vignette 11.3] W. Wallace Cleland (1930-present) received his A.B. from Oberlin College in 1950 and his M.S. and Ph.D. from the University of Wisconsin-Madison in 1953 and 1955, respectively. After a postdoctoral fellowship spent at the University of Chicago he returned to Madison to join the faculty where he remains and is still actively involved in research. Cleland has devoted a great deal of time to developing and using isotope effect techniques to study enzyme mechanisms, see for example J. Biol. Chem. 278, 51975 (2003). (Photo credit Biochemistry Department, University of Wisconsin, Madison)... 

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