Veterans Administration Cooperative study

Veterans Administration Cooperative Study Group,/ Am. Med. Assoc. 202, 116 (1967). 

Veterans Administration Cooperative Study Group on Antihypertensive Agents,/. A.m. Med. Mssoc. 248, 2004 (1982). 

Bartlett JG, Condon RE, Gorbach SL, Clarke JS, Nichols RL, Ochi S Veterans Administration Cooperative Study on Bowel Preparation for Elective Colorectal Operations Impact of oral antibiotic regimen on colonic flora, wound irrigation cultures and bacteriology of septic complications. Ann Surg 1978,188 249-254. 

The treatment of CAD for the alleviation of angina was evaluated in several trials that ultimately shaped the role of coronary angioplasty. Prior to this, trials such as the Veterans Administration Cooperative Study (VA Study) [13, 14] and the Coronary Artery Surgery Study (CASS) trial [15] established the role of revascularization for the improvement in survival and symptom relief A meta-analysis (Table 5.1) regarding surgical revascularization (CABG) versus... 

Murphy ML, Hultgren HN, Detre K, et al. Treatment of chronis stable angina a preliminary report of survival data of the randomized Veterans Administration Cooperative Study. N Engl J Med 1977 297 621. 

Cohn IN et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure Results of a Veterans Administration Cooperative Study. N Engl J Med 1986 314 1547-1552. 

Smith DB, Mattson RH, Cramer JA, Collins JF, Novelly RA, Craft B. Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. Epilepsia 1987 28(Suppl 3) S50-8. 

Lewis HD Jr, Davis JW, Archebald DG, et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina results of a veterans administration cooperative study. N Engl J Med 1983 309 396-403. 

Cohn JN, Archibald DG, Ziesche S, Franciosa JA, Harston WE, Tristan FE, Dunkman WB, Jacobs W, Francis GS, Flohr KH, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study. N Engl J Med 1986 314(24) 1547-52. 

This survey would not be complete without mentioning the Veratrum alkaloids (whose use is limited because of their emetic effect) as well as hydralazine and reserpine. Both of these latter agents still hold a prominent place in the clinical management of patients with hypertension. The placebo-controlled double-blind studies carried out in the Veterans Administration Cooperative Study on Antihypertensive Agents (I) indicated that hydralazine... 

Such results indicate that in the present state of development of antihypertensive drugs any new compound, which in itself may not be sufficiently potent to be relied upon for adequate blood pressure control, may still be clinically useful if its mode of action is different from previously known agents and it does not cause disturbing or dangerous side effects. Such new agents may be useful in combination with other drugs, as shown in the Veterans Administration Cooperative Study. 

The controversy as to whether antihypertensive therapy really prevents complications and alters the mortality prognosis has definitely been settled in favor of drug treatment. The historic Veterans Administration Cooperative Study on antihypertensive agents showed conclusively that major complications in patients with severe hypertension (diastolic pressure of 115-129 mmHg) were reduced by a factor of 27 (Veterans Administration, 1967, 1970). Even patients with moderate hypertension (105-114 mmHg) were found to have morbidity decreased by 4 1. 

Veterans Administration Cooperative Study Group on Antihypertensive Agents (1967) Effects of treatment on morbidity in hypertension, I results in patients, with diastolic blood pressure averaging 115 through 129 nun Hg. J. Am. Med. Assoc. 202 1028-1034. 

Comparative evaluation of prosthetic, reversed, and in situ vein bypass grafts in distal popliteal and tibial-peroneal revascularization, Veterans Administration Cooperative Study Group 141, ArcA. Surg. 1988 123(4) 434-438. 

Simberkoff MS, Cross AP, Al-Ibrahim M, et al. Efficacy of pneumococcal vaccine in high-risk patients results of a Veterans Administration cooperative study. N Engl J Med 1986 315 1318-27. 

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