Coronary artery surgery study

The treatment of CAD for the alleviation of angina was evaluated in several trials that ultimately shaped the role of coronary angioplasty. Prior to this, trials such as the Veterans Administration Cooperative Study (VA Study) [13, 14] and the Coronary Artery Surgery Study (CASS) trial [15] established the role of revascularization for the improvement in survival and symptom relief A meta-analysis (Table 5.1) regarding surgical revascularization (CABG) versus... 

CASS Principal Investigators and their Associates. Myocardial infarction and mortality in the Coronary Artery Surgery Study. N Engl J Med 1984 310 750. 

Myers WO, Davis K, Foster ED, Maynard C, Kaiser GC. Surgical survival in the Coronary Artery Surgery Study. (CASS) registry. AnnThorac Surg 1985 40(3) 245-60. 

Baker ED, Kronmal R, Kennedy JW, Davis K. Comparison of the long-term, postsurgical survival of women and men in the Coronary Artery Surgery Study (CASS). Am Heart J 1989 117(1) 71-81. 

Ross DL, Davis KB, Pettinger MB, Alderman EL, Killip T, Mason JW. Features of cardiac arrest episodes with and without acute myocardial infarction in the Coronary Artery Surgery Study (CASS). Am J Cardiol 1987 60(16) 1219-24. 

An important determinate of outcome for the angina patient is the number of vessels obstructed. Twelve-year survivals from the Coronary Artery Surgery Study (CASS) for patients with zero-, one-, two-, and three-vessel disease were 88%, 74%, 59%, and 40%, respectively. Other factors that increase the risk of death in medically managed patients include the presence of heart failure (or markers such as poor ventricular wall motion and low ejection fraction), smoking, left main or left main equivalent CAD, diabetes, and prior MI. Twelve-year survivals for patients with at least one diseased vessel and ejection fractions in the ranges of 50% to 100%, 35% to 49%, and 0% to 34% are 73%, 54%, and 21%, respectively. Of particular note, patients with left main CAD (or left main equivalent) are... 

Taylor HA Jr, Mickel MC, Chaitman BR, et al. Long-term survival of African Americans in the Coronary Artery Surgery Study (CASS). J Am Coll Cardiol 1997 29 358-364. 

Weiner DA, Ryan TJ, Parsons L, et al. Significance of silent myocardial ischemia during exercise testing in women Report from the Coronary Artery Surgery Study. Am Heart J 1995 129 465 70. 

Kennedy JW, Kaiser GC, Fisher LD, et al. Multivariate discriminant analysis of the clinical and angiographic predictors of operative mortality form the collaborative study in coronary artery surgery (CASS). J Thorac Car-diovasc Surg 1980 80 876-887. 

Abbott AL, Chambers BR, Stork JL et al. (2005). Embolic signals and prediction of ipsilateral stroke or transient ischemic attack in asymptomatic carotid stenosis a multicenter prospective cohort study. Stroke 36 1128-1133 Akins CW (1995). The case for concomitant carotid and coronary artery surgery. British Heart Journal 74 97-98... 

Inoue K, Reichelt W, el-Banayosy A, Minami K, DaUmann G, Hartmann N, Windeler J. Does isoflurane lead to a higher incidence of myocardial infarction and perioperative death than enflurane in coronary artery surgery A clinical study of 1178 patients. Anesth Analg 1990 71(5) 469-74. 

Coronary artery b)q)ass surgery has been used for more than 30 years to treat ischaemic heart disease, but the evidence for its efficacy to reduce mortahty in individual studies has been varied. Some studies have questioned whether bypass surgery while undoubtedly improving quality of... 

Rodriguez A, Bernardi V, Navia J, et al. Argentine randomized study coronary angioplasty wih stenting versus coronary artery bypass surgery in patients with multiple vessel disease 30-day and one year follow-up results. J Am Coll Cardiol 2001 37 51-58. 

Following the Umited success of this procedure, a multicenter phase II/III study is planned in European Union and the United States. The US component of the trial will study the effect of gene therapy in patients with stable angina. The EU component will evaluate patients with advanced coronary artery disease who are not considered candidates for interventions such as angioplasty or coronary artery bypass graft surgery. 

Bashein. G., et al, Preoperative Aspirin Therapy and Reoperation for Bleeding After Coronary Artery Bypass Surgery, Arch. Intern. Med., 114, 835-9 (J991). Dutch TIA Trial Study Group A Comparison of Two Doses of Aspirin (30 mg vs. 283 mg a day) in Patients. After a Transient Ischemic Attack or Minor Ischemic Stroke, N. Eng. J. Med., 1261 (May 1, 1992). 

Inclusion criteria were similar to our previous pilot study (34), Patients with clinical indication of percutaneous coronary revascularization were randomized if they had a de novo severe stenosis in a native coronary artery, a lesion suitable for stent, and a reference vessel size between 2.5 and 4.0 by visual estimation, and were a candidate for coronary bypass surgery, All the PCI procedures were performed at the Catheterization Laboratories at Otamendi Hospital and Sanatorio Las Lomas in Buenos Aires, Argentina. 

Serruys PW, Unger p Sousa JE, etal. Arterial Revascularization Therapies Study Group. Comparison of coronary artery bypass surgery and stenting for the treatment of multivessel disease. N Engl J Med 2001 344 1 117-1124. 

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