Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Vascular protection

Among the local mediators directly produced by endothelium, NO and PGI emerge as two principal regulators of vascular tone and platelet aggregation. Both are sensitive to estrogenic stimuli, and, as mentioned in a previous section, their role is crucial in atherogenesis. How their production is modulated by SERMs is, consequently, an important test of vascular protection. [Pg.227]

Zatta AJ, Matherne GP, Headrick JP (2006) Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart. Life Sci 78(21) 2426-2437 Zhao TC, Kukreja RC (2002) Late preconditioning elicited by activation of adenosine A3 receptor in heart role of NF-kappa B, iNOS and mitochondrial KATp channel. J Mol Cell Cardiol 34(3) 263-277... [Pg.207]

Mason JC. Statins and their role in vascular protection. Clin Sci 2003 105 251-266. [Pg.103]

Schaper W. Dipyridamole, an underestimated vascular protective drug. Cardiovasc Drugs Ther 2005 19 357-363. [Pg.76]

Zachary I, Mathur A, Yla-Herttuala S, Martin J, Vascular protection a novel nonangiogenic cardiovascular role for vascular endothelial growth factor, Arterioscler, Thromb Vase Biol 2000 20(6) I 512-1 520. [Pg.361]

Vascular Protective Actions of VEGF Mediated by NO and PGI2... [Pg.309]

NO and PGI2 produced by VEGF exhibit several other vascular protective effects. They inhibit vascular smooth muscle cell (VSMC) proliferation. The antiproliferative effect of NO and PGI2 on SMCs is mediated via the production of the intracellular messengers cGMP and cAMP, respectively (Asada et al. 1994 von der Leyen et al. 1995). [Pg.309]

NO also inhibits leukocyte adhesion to the endothelium (von der Leyen et al. 1995). NO and PGI2 have antiplatelet actions as well. Thus, via NO synthesis, VEGF can provide protection against proatherogenic factors (Zachary 2001). The overall vascular protective action of VEGF mediated by NO and PGI2 is illustrated in Figure 16.6. [Pg.309]

Fig. 16.6 Vascular protective action of VEGF mediated by NO and PGI2. Fig. 16.6 Vascular protective action of VEGF mediated by NO and PGI2.
Therapeutic angiogenesis Vascular protection Stem cell recruitment... [Pg.314]

Zachary, I. 2001. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am. J. Physiol. Cell Physiol. 280 C1375-C1386. [Pg.326]

The peculiar vascular protective and anti-atherosclerotic properties of lacidipine were further confirmed in the European Lacidipine Study on Atherosclerosis (ELSA), where the carotid atherosclerotic process was slowed down by lacidipine in comparison with atenolol [19]. [Pg.191]

Schiffrin EL. 1998. Vascular protection with newer antihypertensive agents. J. Hypertens. 61(Suppl.) S25-29... [Pg.119]

Hagihara N, Walbridge S, Olson AW, et al. Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107. Cancer Res 2000 60 230-254. [Pg.394]

Treatment of Type 2 Diabetes from a Glucocentric Approach Towards Global Vascular Protection... [Pg.153]

Inhibit damaging effects of enzymes associated with degradation of connective tissue structures Vascular protective activity Antiatherogenic activity... [Pg.33]

An important compound with biological activity of clavines is represented by 6 as end product of EA biosynthesis in A. fumigatus. In animal experiments using rats, 6 exhibited vasorelaxant effects on isolated thoracic aortic rings independent of endothelial mediators. Several mechanisms are proposed for the vasorelaxant effect of 6. These results indicate that 6 has potential capacity in vascular protection and may be used as therapeutic dmg against cardiovascular diseases [78]. Treatment of mice with induced liver damage and colitis with 6 showed clear beneficial effects on these diseases [79, 80]. In addition, it has also been demonstrated that 6 exhibits potential relevance as an antiatherosclerotic agent. Inflammation processes like activation of toll-like receptor 4 (TLR 4) and nuclear factor kB (NFkB) have been shown to be responsible in the development... [Pg.694]

Vascular protection by dietary polyphenols. Eur J Pharmacol 500 299-313 Oak MH, El Bedoui J, Schini-Kerth VB (2005) Antiangiogenic properties of natural polyphenols from red wine and green tea. J Nutr Biochem 16 1-8... [Pg.2244]

Vascular Protection by Wine Polyphenols In Vitro and Ex Vivo Studies. 2366... [Pg.2361]

See other pages where Vascular protection is mentioned: [Pg.330]    [Pg.384]    [Pg.385]    [Pg.330]    [Pg.193]    [Pg.147]    [Pg.45]    [Pg.590]    [Pg.200]    [Pg.493]    [Pg.599]    [Pg.273]    [Pg.421]    [Pg.154]    [Pg.280]    [Pg.227]    [Pg.269]    [Pg.110]    [Pg.230]    [Pg.2361]    [Pg.2361]    [Pg.2362]    [Pg.2365]    [Pg.2367]    [Pg.2369]    [Pg.2371]    [Pg.2373]    [Pg.2375]   


SEARCH



© 2024 chempedia.info