Vanadium biological origin

C. Biological Origin Vanadium in Tunicate Blood Cells... 

Her research interests originally focused on biological cell membranes, first working on phosphate transport in Escherichia coli and then the plasma membrane proton ATPase in Saccharomyces cerevisiae. While isolating vanadate-resistant mutants in yeast, she became fascinated with work showing that oral administration of vanadium salts alleviated symptoms of diabetes and switched her research focus to that area. She has pursued the insulin-enhancing mechanism of vanadium salts and complexes in cell culture, the STZ-induced diabetic rat, and human type 2 diabetic patients. The National Institutes of Health, the American Heart Association, and the American Diabetes Association have funded the work in her laboratory. Willsky has lectured all around the world and published both research articles and book chapters in this area. 

Teissedre, P.L., Cros, G., Krosniak, M., Portet, K., Serrano, J.J., and Cabanis, J.C. (1996b) Contribution of wine in vanadium dietary intake geographical origin has a signicant impact on wine vanadium levels. In Ph. Collery, J. Corbella, J.L. Domingo, J.C. Etienne, and J.M. Llobet (Eds.), Metal Ions in Biology and Medicine , vol. 4, John Libbey Eurotext, Paris, p. 183. 

All of the findings in the biological chemistry of vanadium have their history. In order to appreciate and to value the impact of early perceptions and their protagonists, I have analysed a couple of early and original documents on, e.g., vanadium nitrogenase, vanadium in the blood of ascidians and vanadium compounds as a remedy for a plethora of diseases. Snapshots of these historical events have been included. Included, in the first chapter, is also a detailed account on the discovery of vanadium. 

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