Validamycins activity against

Validamycin A is the only commercial fungicide active against this target (Figure 4.9). The compound is an aminoglycosidic pseudosaccharide and is a secondary metabolite produced in the fermentation of Streptomyces hygroscopicus var. limoneus. Validamycin A was introduced by Takeda Chemical Industries Ltd. for the control of Basidiomy-cetes and Corticiaceae, especially sheath blight, Rhizoctonia solani, in rice. 

The first evidence for aminocarbapyranoses occurring in Nature dates back to early 70s with the discovery of validamine 202 (Chart 3), a carbasugar constituent of Validamycins, an antibiotic complex which shows growth inhibition activity against bacterial diseases of rice plants [50]. Shortly after, validamine 202, along with valiolamine 203 and valienamine 204, (Chart 3), were isolated from the fermentation broth of Streptomyces hygroscopicus var. limoneus [50],... 

C20H35NO13 497.495 Isol. (tom Streptomyces hygroscopicus and Streptomyces prasinus as major component of Validamycin complex. Also obt. on chemical or enzymic hydrol. of Validamycin C, V-2, Validamycin E and Validamycin F. Used in control of fungal infection in rice, potatoes, strawberries and other crops. V. active against Pellicularia sasakii. Amorph. powder. Sol. H2O, MeOH, DMSO, DMF fairly sol. EtOH, Me2CO poorly sol. EtOAc, hexane, Et20. Mp 95° dec Mp 130-135° dec. [a]o +112 (c, 1 in H2O). pAa 6. 

Activity of Validamycins and Validoxylamines against Pellicularia sasakii... 

Inhibitory Activity (M) of Validamycin and Validoxylamine against Trehalase... 

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