Valeriana jatamansi

Selenicereus grandiflorus flower, stem Tetradium ruticarpum unripe fruit Valeriana edulis ssp. procera rhizome, root Valeriana jatamansi rhizome, root Valeriana officinalis rhizome, root Valeriana sitchensis rhizome, root Zingiber officinale rhizome... 

Volvaltrate B (132) isolated from both Valeriana jatamansi and V. officinalis also showed significant in vitro cytotoxic activity against A549, PC-3 M, HCT-8, and Bel 7402 cells with IC50 values of 8.5, 2.0, 3.2, and 6.1 pM, respectively, in the MTT assay [147]. 

Ayurvedic medicine (India) Occasional adulterant in chharUa (see Parmotrema nilgherrense). Mixed with other aromatic herbs, such as Valeriana jatamansi for favoring and curing tobacco, along with U. longissima, U. subsordida, Everniastrum nepalense, E. cirrhatum, and Ramalina inflata (Shah 1998)... 

The rhizomes and roots of Valeriana wallichii DC. contain 6-methylapigenin, which is a competitive ligand for GABAa receptor (38). In the Asia-Pacific region, Nar-dostachys chinensis L., Nardostachys jatamansis DC., Patrinia scabiosaefolia Link, Valeriana officinalis L., Valeriana dageletiana Nak. ex Maekawa, and Valeriana hardwickii Wall, are used as alternative remedies. 

Iridoid alkaloids have been recognized in the family. In this study, the following were positive Nardoslachys jatamansi (2/2), Valeriana capitata, V. ceratophylla, V. cleinatitis (2/2), Valeriana sp. indcL (1/3), V urticaefolia (1/2), V vaginata. 

The genus Valeriana contains about 250 species in the world. Majority of representatives of this genus are distributed over the temperate regions. The three most important species that play a role in herbal medicine are V officinalis L., V. jatamansi Jones (synonym V. wallichii DC.) and V edulis Nutt, ex Torr. and Gray ssp. procera H.B.K. 

In contrast, valeranes arising from migration of flie methyl group C-15 in eudesmane from C-4 to C-5, in contrast, very rarely occur. Examples include the va-lerenones from the roots of valerian Valeriana officinalis and from Nardostachys jatamansi (Valerianaceae). 

Valeranone (254) (194), a component of the roots of Valeriana officinalis and of the rhizomes of Nardostachys jatamansi was the first compound to be recognized among a minor group of rearranged eudesmanes in which C-3 methyl (farnesol numbering) has undergone a 1,2-shift. Cryptofauronol (255) is another related compound isolated from Japanese valerian (197). 

Markownikoff cyclization of 353 is represented by maaliol (360), a component of Maali resin, a soft exudate from Canarium samonense (275 vol. Illb). A related compound is maalioxide (361) from roots of Valeriana wallichii (305). Rearrangement of maaliane cation 355 (cf. Fig. 8.1.11), as shown in Fig.8.1.16, leads to the carbon skeleton of aristolene (362), which occurs in the essential oil from roots of Nardostachys jatamansi. (-i-)-Aristolene (a-ferulene) is present in the latex of Ferula communis (312). From roots of Aristolochia debilis, hydroxyketone 363 has been isolated (241). 

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