Aristolochia debilis

Hong et al. showed that a methanol extract of Aristolochia debilis is a potent inhibitor of COX-2 activity (7). 

The octahydrohydroperoxy-(5//)-cyclopropa[a]-naphthalen-5-one 69 (P2i2i2i, O— O = 1.453) has been extracted from the underground part of the plant Aristolochia debilis. The plant is used in traditional Chinese medicine to cure airway disorders. Hydroperoxide 69 has been prepared independently upon exposure of a suitable deperoxy derivative to air. 

Aristolochia debilis Sieb. et Zucc. Qing Mu Xiang (root) Aristolochic acid, debilic acid, magnoflorine, dibilone, cyclanoline, aristolone.33 Antihypertensive, lower heart rate and myocardial contractility, vasodilatation. 

Aristolochia shimadai, A. debilis, Clematis armandii, C. heracleifolia Aristolochia contorta, A. kaempferi, A. longa, A. recurvilabra Aristolochia contorta, A. kaempferi, A. longa, A. recurvilabra Aristolochia debilis... 

Aristolochia debilis, Stephania japonica, S. tetrandraq, S. cepharantha Abrus precatorius, Euphorbia antiquorum... 

A 49-year-old woman developed signs of hepatitis. All the usual causes were ruled out. The history revealed that she had recently started to use a Chinese herbal tea to treat her eczema. Examination of the herbal mixture showed that it contained Aristolochia debilis root and seven other medicinal plants. 

P. amurenae Rupr. var. Palmatine Phellodendrine Candicine Magnofiorine Berberine Aristolochia debilis Sieb. et Zuoc. (71) Cyclanoline Magnofiorine ... 

Aristolactam (74) Aristolochia debilis Sieb. et Zucc. Aristolochia indica... 

Ishwaranes represent 7-11/10-12-bicycloeremophilanes. These rare tetracyclic sesquiterpenes are found in Aristolochiaceae, for example ishwarane itself and ish-waranol in the roots of Aristolochia indica and 3-ishwaranone from Aristolochia debilis. 

Aristolochia debilis (Aristolochiaceae) is a perennial vine that grows wild in the plains and on the banks of the rivers in Japan.The dried roots are called Sei-mokkoh or Do-sei-mokkoh, and the dried fruits are called Ba-to-rei, and are used in Kampo medicine. The dried roots are used as an antipyretic, and the dried fhrits as a sedative, antitussive, and to clear the throat. In Korea and China, Anhalonium contorta and Anhalonium kaempferi are used instead of A. debilis. 

Markownikoff cyclization of 353 is represented by maaliol (360), a component of Maali resin, a soft exudate from Canarium samonense (275 vol. Illb). A related compound is maalioxide (361) from roots of Valeriana wallichii (305). Rearrangement of maaliane cation 355 (cf. Fig. 8.1.11), as shown in Fig.8.1.16, leads to the carbon skeleton of aristolene (362), which occurs in the essential oil from roots of Nardostachys jatamansi. (-i-)-Aristolene (a-ferulene) is present in the latex of Ferula communis (312). From roots of Aristolochia debilis, hydroxyketone 363 has been isolated (241). 

Krepinsky J, Jommi G, Samek Z, Sorm F 1970 On terpenes. CCIV. The sesquiterpenic constituents of Aristolochia debilis Sieb. et Zucc. The structure of debilone. Collect Czech Chem Com-mun 35 745-748... 

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