Vaccaria segetalis

Gentiana asclepiadea (Gent.) Vaccaria segetalis (Caryo.) Xanthosoma violaceum (Arac.) Arena saliva (Gram.)... 

Saponaria officinalis L. S. vaccaria L. (Syn. Vaccaria segetalis) Wang Bu Liu Xing (Cow herb) (seed, root) Saponarin.65 This herb is contraindicated in pregnancy. For abscesses, furuncles, ulcers, scabies, mastitis, lymphangitis. Root is used to treat syphilis, glandular and chronic skin disease. 

Saponaria officinalis L., S. vaccaria L., Vaccaria segetalis (Neck.) Garcke Cassia torn L., C. occidentalis L. 

Examples of naturally occurring bioactive cyclopeptides are Segetalins A and B (Figure 1.3.11), which were isolated from Vaccaria se.gd.alis (Caryophyllacea) and were shown to have estrogen-like activity. The seeds of Vaccaria segetalis are used... 

Fig. 1.3.11. Segetalin A and Segetalin B isolated from Vaccaria segetalis (Caryophyllacea).

Segetalins A B Vaccaria segetalis (Caryophyllaceae) Oestrogen-like... 

For fibrocystic lumps and mammary hyperplasia, add Squama Manitis (Chuan ShanJia) and Semen Vaccariae Segetalis (Wang Bu Liu Xing) to dispel stasis, soften the hard, and scatter nodulation. 

For fibrocystic breasts, subtract Licorice and add Semen Vaccariae Segetalis (Wang Bu Liu Xing), Caulis Millettiae Seu Spatholobi (Ji Xue Teng), Radix Salviae Miltiorrhizae (Dan Shen), and Rhizoma Cyperi Rotundi (Xiang Fu). 

Saponins of Gypsophila plant facilitate the release of intracellular K+ and lactate dehydrogenase in rat hepatocytes, suggesting that they destabilize the plasma membrane [127] by removing membrane lipids [128]. Furthermore, Gypsophila plant derived saponins induce differential permeability of the intracellular membrane of rat hepatocytes [129], Vaccaroid A, a triterpenoid saponin from Vaccaria segetalis [130], induces contractivity of rat uterus. 

The seeds of Vaccaria segetalis (Caryophyllaceae) have been used to stimulate blood flow and promote milk secretion, and also to treat amenorrhea and breast infections in China (224). Extraction and purification of chemical constituents showing follicle hormonic activity led to the isolation of the new, bioactive cyclic peptides segetalins A-H (322-329) (225-228). Some segetalins showed potent estrogen-like activity. Although some cyclic peptides such as oxytocin and vasopressin show hormone activities, none show estrogen-like activity. 

Fig. 42. Structures of segetalins A-H (322-329) from the seeds of Vaccaria segetalis.

Vaccaria segetalis (Neck) Garke ex. Asch., Vaccaria vulgaris Host. 

Semen Vaccariae / Vaccaria segetalis Sample of commercial drug obtained from TCM-Clinic Bad Kotzting... 

Koike, K, Jia, Z, Nikaido, T Triterpenoid saponins from Vaccaria segetalis. Ph3dochemistry 47(7), 1343-1349 (1998)... 

Qi, P, Zhang, F, Xue, R, Li, Z, Chen, M, Sun, Z, Zhu, K, Huang, C Identification of multiple constituents from seed of Vaccaria segetalis with an adsorben-separation strategy based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Rapid Commim. Mass Spectrom. 28(11), 1243-1257 (2014)... 

Itokawa, H, Yun, Y, Morita, H, Takeya, K, Yamada, K Estrogen-hke activity of cyclic peptides from Vaccaria segetalis extracts. Planta Med. 61(6), 561-562 (1995)... 

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