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Ultra high performance liquid chromatography UPLC

One new technology that has been found to be very useful for various HPLC-MS/MS applications is ultra-high-performance liquid chromatography (UPLC) (Yu et al., 2006, 2007). UPLC takes advantage of the improvement in... [Pg.397]

Crockford et al. utilized tfre freterospectroscopic methodology to investigate metabolic mixtures [52,53]. They concatenated spectral data from NMR and ultra high-performance liquid chromatography (UPLC) coupled to MS to obtain NMR—MS covariance maps. The approach was baptized SHY as an acronym of statistical heterospectroscopy. [Pg.294]

Ultra high performance liquid chromatography (UPLC), 3593... [Pg.4239]

Ultra high performance liquid chromatography (UHPLC) or ultra performance liquid chromatography (UPLC) is a quite novel technique, but it is one of the most popular nowadays, due to the fact that it is much more rapid than conventional LC. UHPLC systems can work at very high pressures and are compatible with stationary phases with particle sizes of around two micrometers or even smaller. Thus, the development of UHPLC methods [69,77, 80] or the conversion of HPLC to UHPLC methods is a current trend, due mainly to the speed of analysis and low solvent use. [Pg.4356]

Ultra-high performance liquid chromatography quadrupole-time-of-flight-mass spectroscopy, UPLC-QqTOFMS, was used for studies of possible contaminants in post-harvest pears and apples." Fifteen percent samples contained erucamide." ... [Pg.285]

Abbreviations AM, amlodipine AT, atorvastatin DS, diclofenac sodium EZ, ezetimibe FB, fenofibrate HAT, hydroxy atorvastatin IS, internal standard o-HAT, ortfio-hydroxy atorvastatin p-HAT, para-hydroxy atorvastatin HPLC-ESI-MS, high-performance liquid chromatography with electrospray tandem mass spectrometry LV, lovastatin NA, nicotinic acid NB, novobiocin FV, pravastatin RV, rosuastatin SV, simvastatin RT, roxethromycin UPLC, ultra performance liquid chromatography. [Pg.67]

Also, new-generation HPLC instrument which can exceed the pressure limitation of conventional equipment has been developed. This technique is ultra performance liquid chromatography (UPLC), where small particle size columns with 1.7 pm particle size in combination with high flow rates offers increased speed, resolution, and sensitivity [15]. Ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has shown to be well suited for support of PK studies [16-19], Often, there is a need to improve the sensitivity of the assay for the determination of PK parameters, especially for very potent compounds, since lower amount is administrated, and also for compounds with low bioavailability. UPLC-MS/MS has shown decreased ion suppression and superior sensitivity, and has been successfully applied to PK studies for compounds with low bioavailability [20-22]. [Pg.191]

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See also in sourсe #XX -- [ Pg.35 ]



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