Ubiquitin carboxy-terminal hydrolase

In addition to the RC subunits detected in all eukaryotic organisms investigated so far, a few subunits seem to be species-specific. A member of the ubiquitin carboxy-terminal hydrolases (UCH) (Wilkinson 2000), has been found in Drosophila (p37A) (Holzl et al. 2000), S. pombe (Uch2) (Li et al. 2000), and human (UCH37) (Li et al. 2001), but not in S. cerevisiae 26S proteasomes. The Drosophila p37A subunit was mapped to the base-lid interface in close vicinity of the putative location of S5a/Rpnl0 (Holzl et al. 2000). 

Solano, S. M., Miller, D. W., Augood, S. J., Young, A. B., Penney, J. B., Jr. 2000. Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase LI mRNA in human brain genes associated with familial Parkinson s disease. Ann Neurol 47 201-10. 

Ubiquitin-carboxy terminal hydrolase Antigen processing IHC.WB Lichtenfels et al, 2003... 

Ubiquitin carboxy-terminal hydrolase L-1 Oxidation in AD Castegna et al. 2002a... 

Maekesbeey, W. R., Butteeeield, D. A. (2002a). Proteomic identification of oxidatively modified proteins in Alzheimer s disease brain. Part I creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radio. Bid. Med. 33, 562-571. 

Maraganore DM, Farrer MJ, Hardy JA, Lincoln SJ, McDonnell SK, Rocca WA (1999) Case-control study of the ubiquitin carboxy-terminal hydrolase LI gene in Parkinson s disease. Neurology 53 1858-1860... 

Mellick GD, Silburn PA (2000) The ubiquitin carboxy-terminal hydrolase-Ll gene S18Y polymorphism does not confer protection against idiopathic Parkinson s disease. Neurosci Lett 293 127-130... 

Osaka H, Wang YL, Takada K, Takizawa S, Setsuie R, Li H, Sato Y, Nishikawa K, Sun YJ, Sakurai M, Harada T, Hara Y, Kimura 1, Chiba S, Namikawa K, Kiyama H, Noda M, Aoki S, Wada K (2003) Ubiquitin carboxy-terminal hydrolase LI binds to and stabilizes monoubiquidn in neuron. Hum Mol Genet 12 1945-1958... 

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