Tumor seeding

Konno, K., Ishida, H., Hamashima, Y., Komatsuda, T., Sato, M., Furu-ya, T., Asanuma, Y., Masamune, O. Color Doppler findings of tumor seeding after US-guided liver tumor biopsy. Abdom. Imag. 1999 24 401-403... 

The physical examination in patients with gastric adenocarcinoma is nsnally normal. In advanced disease, a palpable abdominal mass, hepatomegaly, or ascites may be present. Lymph nodes may be palpated at the umbilicns (Sister Mary Joseph s node) or the supraclavicular region (Virchow s node). A perirectal mass may occur, with tumor deposition in the rectal pouch (Blumer s shelf), and palpable ovarian enlargement may occur with tumor seeding as well (Krukenberg tumor). 

Tumor seeding is demonstrated as a hypoechoic nodule on the visceral or parietal peritoneum (Fig. 16.10c). Often ascites with floating echogenic particles accompanies tumor seedings, indicating peritonitis carcinomatosa. 

On a large scale, chemotherapy and radiation may be effective on several levels. The concept of spatial interaction was devised to mean that chemotherapy and radiation act on spatially distinct compartments of the body, resulting in a net gain in tumor control. The concept of spatial interaction does not take into account any drug-radiation interaction on the level of the tumor itself, but rather assumes that radiation or chemotherapy would be active in different compartments, respectively. In a narrow sense, this concept describes the fact that chemotherapy would be employed for the sterilization of distant microscopic tumor seeding, whereas radiation... 

Llovet JM, Vilana R, Bru C et al (2001) Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma. Hepatology... 

Immediately after the mice bladder instillation, the 1x10 MBT2 cells were inoculated via the urethra for tumor seeding. In order to evaluate the tumor progression, the mice were sacrificed for section examination on each 14 days post-inoculation. 

Kanematsu M, Hoshi H, Takao H et al (1997) Abdominal wall tumor seeding at sonographically guided needle-core aspiration biopsy of hepatocellular carcinoma. AJR Am J Roentgenol. 169 1198-1199... 

Llovet JM, Vilana R, Bru C, et al (2001) Barcelona Clinic Liver Cancer (BCLC) Group. Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma. Hepatology 33 1124-1129 Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362 1907-1917... 

Risk of bleeding and thrombosis, additional risk of zoonosis or tumor seeding... 

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