Tumor-infiltrating dendritic cells

Induction of iNOS Gene and NO by Tumor-Infiltrating Dendritic Cells... 

Eioretti, E., Eradelizi, D., Stoppacciaro, A., Ramponi, S., Ruco, L., Minty, A., Sozzani, S., Garlanda, C., Vecchi, A., and Mantovani, A. (1998). Reduced tumorigenicity and augmented leukocyte infiltration after monocyte chemotactic protein-3 (MCP-3) gene transfer perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor. J. Immunol. 161, 342-346. 

In addition to the role that CC chemokines play in promoting TAM infiltration, CC chemokines may also play an important role in enhancing effective immune antitumor responses. Certain CC chemokines have the ability to recruit specific Thl lymphocytes and dendritic cells that would serve as a rationale for immunotherapy in cancer. Recently, Sharma and associates have found that secondary lymphoid tissue chemokine (SLC also referred to as Exodus 2 or 6Ckine) has the ability to suppress tumor growth by recruitment of mononuclear cells (136). Intratumoral injection of recombinant SLC in syngeneic murine lung m-... 

LPS or IFN-y activated rat dendritic cells, which produce high amounts of IL-12 and TNF -a, kill several tumor cells (colon carcinoma) but requires cell-to-cell contact, and depends on NO production in vitro. Moreover, intratumoral injection of LPS induces an increase of iNOS expression in tumor-infiltrating DCs and a significant arrest of tumor growth in vivo (Nicolas et al. 2007). 

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