Secondary lymphoid-tissue chemokine

Biber K, Sauter A, Brouwer N, et al. Ischemia-induced neuronal expression of the microglia attracting chemokine secondary lymphoid-tissue chemokine (SLC). Glia 2001 34 121-133. 

Rappert A, Biber K, Nolte C, et al. Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl-current and chemotaxis in murine microglia. J Immunol 2002 168 3221-3226. 

Nagira, M., Imai, T., Hieshima, K., Kusuda, J., Ridanpaa, M., Takagi, S., Nishimura, M., Kakizaki, M., Nomiyama, H., and Yoshie, O. (1997). Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a... 

Saeki, H., Moore, A. M., Brown, M. J., and Hwang, S. T. (1999). Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162, 2472-2475. 

Yoshida, R., M. Nagira, M. Kitaura, N. Imagawa, T. Imai, and O. Yoshie. 1998. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J Biol Chem 273 7118-7122. 

S. M. Dubinett. Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo. J Immunol 164 4558-63, 2000. 

Nagira M, Imai T, Yoshida R, Takagi S, Iwasaki M, Baba M, Tabira Y, Akagi J, Nomiyama H, Yoshie O. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine, SLC, is a highly efficient chemoattractant for B cells and activated T cells. Eur J Immunol 1998 28 1516-1523. 

Chan VWF, Kothakota S, Rohan MC, Panganiban-Lustan L, Gardner JP, Wachow-icz MS, Winter JA, Williams LT. Secondary lymphoid tissue chemokine (SLC) is chemotactic for mature dendritic cells. Blood 1999 93 3610-3616. 

In addition to the role that CC chemokines play in promoting TAM infiltration, CC chemokines may also play an important role in enhancing effective immune antitumor responses. Certain CC chemokines have the ability to recruit specific Thl lymphocytes and dendritic cells that would serve as a rationale for immunotherapy in cancer. Recently, Sharma and associates have found that secondary lymphoid tissue chemokine (SLC also referred to as Exodus 2 or 6Ckine) has the ability to suppress tumor growth by recruitment of mononuclear cells (136). Intratumoral injection of recombinant SLC in syngeneic murine lung m-... 

Kirk, C. J., Hartigan-O Connor, D., Nickoloff, B. J., Chamberlain, J. S., Giedhn, M., Aukerman, L., et al. (2001). T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine Augmentation of dendritic cell-based immunotherapy. 

Pachynski, R. K., Wu, S. W., Gunn, M. D., and Erie, D. J. (1998). Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J. Immunol. 161,... 

Nomura, T., Hasegawa, H., Kohno, M., Sasaki, M., and Fujita, S. (2001). Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1 alpha chemokine genes. Int. J. Cancer 91, 597-606. 

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