Tumor cell-killer lymphoid cells

VDUPl mice displayed immune system defects, including perturbed development and function of natural killer (NK) cells. There was a profound reduction in the numbers of NK cells and in NK activity in VDUP1 mice, which showed minimal changes in T and B cell development (Lee et al. 2005). The NK cell abnormality in the VDUP1 mice caused severe lymphoid hyperplasia in the small intestine and reduced tumor rejection (Lee et al. 2005). Moreover, the percentage of hepatic natural killer T (NKT) cells in VDUPl" " mice was decreased, and the percentage... 

The lymphomas are neoplasms of B-, T- or natural killer cells, and characteristically present as tumorous enlargements of peripheral lymphoid or extranodal tissues. As with the leukemias, the lymphomas are subclassified into distinct clinicopathological entities based on lineage, cell of origin and/or putative normal counterpart, and degree of differen-... 

Evidence from injection studies in animals corroborates the sensitivity of the immune system to radioactive strontium. In mice that have been injected with 89Sr or 90Sr to deplete bone marrow, natural killer cells are preferentially eliminated. The loss of this cell population results in a reduced ability to defend against lymphoid tumors. In similar injection studies, adverse effects have were also observed in the spleen and thymus. 

Tumor Immunity. At the present time it has not been resolved as to whether the primary in vivo mechanisms of lymphoid-mediated tumor rejection results from the activity of sensitized cytotoxic T cells or non-T natural killer cells (NK cells) (Herberman, 1981) or both. Several of the well-... 

---