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Tumor necrosis factor biological actions

Thalidomide (Thalomid) is a derivative of glutamic acid that is chemically related to glutethimide. It exerts a number of biological effects as an immunosuppressive, antiinflammatory, and antiangiogenic agent, yet its mechanisms of action have not been fuUy elucidated. Thalidomide potently inhibits production of tumor necrosis factor (TNF) a and interleukin (IL) 12, and its effect on these and other cytokines may account for some of its clinical effects. [Pg.490]

Gordon, J.R and Galli, S.J. (1991). Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. J. Exp. Med. 174, 103-107. [Pg.77]

See other pages where Tumor necrosis factor biological actions is mentioned: [Pg.445]    [Pg.956]    [Pg.239]    [Pg.1328]    [Pg.27]    [Pg.147]    [Pg.188]    [Pg.269]    [Pg.64]    [Pg.356]    [Pg.4006]    [Pg.120]    [Pg.411]    [Pg.987]   
See also in sourсe #XX -- [ Pg.704 , Pg.705 , Pg.706 ]



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Biological action

Biological factors

Tumor biology

Tumor necrosis

Tumor necrosis factor

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