HIF-1 in Tumor Biology

As proposed schematically in Fig. 13.2, RNI may block PHD-activity, attenuate proline hydroxylation of HIF-la, dissociate HIF-la from pVHL with the consequence of protein stabilization based on decreased proteasomal degradation. 

The critical role that HIF-1 plays in cancer biology can be deduced from immunohis-tochemistry data showing elevated levels of HIF-la in a variety of primary malignant 

RNI have not been considered classical, i.e. originally identified activators of p53 or HIF-la. This provokes the question of the relevance of RNI in activating gene 

Energy metablism Angiogenesis Iron homeostasis Cell proliferation Cell viability Inflammation 

We apologize to researchers whose primary observations that form the basis for our current knowledge in this active field could not be cited due to space limitations, or have been acknowledged indirectly by citing review articles, only. Our work was supported by grants from Deutsche Forschungsgemeinschaft (Br 999), Deutsche Krebshilfe (10-2008-Br2) and the Sander Foundation (2002.088.1). 

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