Tuberculosis laboratory tests

CDD Collaborative Drug Discovery Repository of small-molecule libraries of more than 300,000 compounds derived from patents, literature, and high-throughput screening data shared by academic and pharmaceutical laboratories tested against M. tuberculosis preliminary public antimalarial database from multiple sources on 30,000 public compounds (https //www.collaborativedrug.com/pages/public access)... 

Lederer s work began with the knowledge that mycobacteria, the bacteria that cause tuberculosis, have long been known to enhance immune response, and extracts of these germs have been widely used as immuno-adjuvants in laboratory tests. The best known of these laboratory aids is Freund s Adjuvant... 

Established Drugs - The oxidative degradation of ethionamide to sulfoxide and other products vitro was studied with relation to activity in tuberculosis. A test for ethionamide sulfoxide in urine was devised so that clinicians could check that patients were ingesting the drug. Clinical and laboratory experience with ethambutol was reported in I5 papers and was summarized by Herman. The pro and con of the isoniazid prophylaxis of tuberculosis was discussed, and the production of hepatic carcinoma in mice with this agent was disclosed.The metabolism of doubly labeled thiocarlide XIII was studied in humans. Blood levels were 10-12 mcg/ml from doses 6 g per day, twice the level seen in rabbits. 

In vitro evaluation of anti-tuberculosis activity was conducted for fifty-six quassinoids isolated in our laboratory from the Simaroubaceous plants A. altissima (10 compounds), B. antidysenterica (16 compounds), P. ailanthoides (14 compounds), and B.javanica (16 compounds), as shown in Table 15. Of the compounds tested, shinjulactone-K (119)... 

Many PCR diagnostic kits are now commercially available. Hoffman-La Roche has introduced kits for Chlamydia, M. tuberculosis, HTV, hepatitis C virus, and others. It is likely that an even wider range of PCR diagnostic kits will become available, and PCR testing will continue to have a huge impact in the clinical diagnostic laboratory. Despite the simplicity and rapidity of PCR from the perspective of the research laboratory, it is viewed as a complex test in the clinical laboratory. The expenses of highly... 

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