Triglycerides hybrid

Hybrid triglycerides (RCOOCH2-CH(OCOR )-CH2OCOR"), i.e., containing zero, one, or two natural fatty acyl substituents, and three, two, or one active carboxylate moieties ... 

In an attempt to improve the pharmacokinetic properties of hybrid triglyceride prodrugs, a number of hybrid pseudolipid analogues were prepared with the glyceryl moiety replaced by a 1,3-diaminopropyl moiety. As... 

The interesterification of fats and oils is the only way to create new hybrid products with new physical, and especially new rheological properties. Chemical interesterification is well known, but has no position or chain specificity, and is not very clean. With lipases in micro-aqueous media, the exchange of acyl groups between the different triglycerides may be oriented, and designed according to the specificity of the enzyme. 

Van Hamersveld et al. [176, 177] carried out hybrid miniemulsion polymerization of MMA, using HD as the costabihzer. In an attempt to encourage grafting, oxidized triglycerides (such as sunflower oil) were used as initiators. 

Birukov, O., Figovsky, O., Leykin, A., Potashnikov, R., and Shapovalov, L. Method of Producing Hybrid Polyhydroxyurethane Network on a Base of Carbonated-Epoxidized Unsaturated Fatty Acid Triglycerides, US Patent 20120208967 applied for in 2012. 

Studies investigating stereoselective binding and distribution of NSAIDs to extrasynovial tissues are scarce. In rats, etodolac displays less stereoselectivity in tissue concentrations than in plasma and was thought to be due to a greater unbound fraction of S enantiomer in plasma relative to antipode [275]. For 2-aryl propionates, which undergo in vivo unidirectional inversion from R to S enantiomer (e.g., ibuprofen), the presence of these NSAIDs in the adipose tissue as hybrid triglycerides has been reported [276]. 

Figure 2 An example of a hybrid-triglyceride in which ibuprofen has replaced the neutral fatty acid palmitic acid.

Another possible application where the typically low viscosity of microemulsions is very useful is in the preparation of alternative fuels for diesel engines. Such hybrid fuel microemulsions containing vegetable oil [13] and alcohols, with 1-butanol [14] or a lower trialkylamine [15] acting as surfactant attracted interest some years ago, and such systems were tested for their practical application [16]. Similar systems containing triglyceride, aqueous ethanol, and 1-butanol [17] or long-chain fatty alcohols [18] were also studied for the same purpose. 

The combination with fibres has proved difficult however. Often there are issues with compatibility between bio-resins and fibres (both natural and synthetic), which cause defects in the composite structure and ultimately poorer physical properties. Castor-oil polyurethane was compared with phenolic resins when infused over sisal fibres however, the phenolic resins showed better structural performance when compared with the castor oil-based material [52]. This is not always the case, as some improvements have been made. Soybean oil thermoset polymers were used in a glass/flax hybrid composite resulting in improved mechanical performance [73], Thermoset resins were produced from triglyceride oils with a wide range of properties (tensile modulus 1-2 GPa, glass transition temperature Tg 70-120 °C) and glass- and hemp- fibre composites were manufactured [74,75]. 

Hybon 2011. See Glass Hybrid safflower (Carthamus tinctorius) oil Synonyms Carthamus tinctorius Carthamus tinctorius hybrid oil Carthamus tinctorius oil Hybrid safflower oil Safflower oil, hybrid Definition Oil derived from safflower seeds of a generic strain (hybrid safflower) which contains predominantly oleic acid triglyceride Properties Bland liq. insol. in water sol. in oil Uses Solubilizer, emollient, conditioner, gloss aid, solvent for cosmetics and pharmaceuticals and in cooking oils... 

Castor oil benzoate gloss aid, cosmetics Apricotamidopropyl ethyidimonium ethosulfate Arachidyl behenate Avocado (Persea gratissima) oil Behenamidopropyl ethyidimonium ethosulfate Brassica campestris/Aleurites fordi oil copolymer Cl8-36 acid triglyceride Cl 8-28 alkyl acetate Cetyl octanoate Hybrid safflower (Carthamus tinctorius) oil Hydroxypropyltrimonium hydrolyzed silk... 

Multiple emulsions of the oil-in-water-in-oil type, where both the inner and the external oil phases were medium chain triglyceride (MCT), were prepared by the two-step emulsification method. The emulsifying agent at the inner oil-water interface was a combination of WPI-xanthan gum hybrid at different ratios and 3wt% Abil EM90 (a hydrophobic polyether-polysiloxane block copolymer) as the external emulsiher. Typical multiple emulsion composition is described in Table 7.2 and release profiles of flumethrin (a veterinary drug model) at 25°C are presented in Figure 7.15. 

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