Triclosan antibacterial activity

Direct InhA inhibitors have also been sought to avoid isoniazid resistance mediated by catalase-peroxidase mutation. Lipophilic analogs of triclosan such as 36 show a nanomolar K on the enzyme with an MIC of 1-2 pg/mL on isoniazid-resistant strains [56]. Structure-based optimization of two separate HTS leads afforded 37 and 38, both submicromolar inhibitors of InhA but devoid of any significant antibacterial activity [57,58],... 

Triclosan Trichloro- Good antibacterial activity, Slight antibiotic activity,... 

Triclosan (2,4,4,-trichloro-2/-hydroxydiphenylether) is an antiseptic suitable for formulation in a W/O emulsion with excellent antibacterial activity in vitro and in vivo against S. aureus, Klebsiella and Proteus species 26 In addition, it has been shown to be effective for eradication of MRSA as well as fungi. Triclosan does not have irritative, phototoxic or allergic, nor mutagenic or teratogenic potential the toxicity in general is low and so is the sensitizing potential.27-29 Triclosan and similar additives (e.g., triclocarban) have demonstrated antibacterial and antiinflammatory efficacy when used as an antiseptic wash.28,30... 

Triclosan cannot only be applied as an emulsion, but it also has demonstrated antibacterial and antiinflammatory efficacy in eczema therapy when used as an antiseptic wash.28,30 Likewise, 10% povidone-iodine solution as a disinfectant showed excellent antibacterial activity together with improvement of clinical severity.79 As a 1% solution, chlorhexidine digluconate has shown superior effectiveness to triclosan in vitro, but may be only suitable for therapeutic use in intertriginous areas or as part of wet wrap dressings in the treatment of AD when used as an alcoholic solution.26,80... 

Triclosan is highly substantive to many surfaces including skin, fabric, and hair, and can provide residual bacteriostatic activity. The residual antibacterial activity is summarized in Table 7.20 and Table 7.21. 

Suarez S, Dodd MC, Omil F et al. (2007) Kinetics of triclosan oxidation by aqueous ozone and consequent loss of antibacterial activity relevance to municipal wastewater ozonation. Water Res 41(12) 2481... 

From an assessment of antibacterial activity, the resnlts show that untreated, plasma treated and acrylic-acid grafted samples did not display any antibacterial activity against strains of Escherichia coli and Staphylococcus aureus. The sample coated with triclosan met the expected antibacterial requirements and similar results were obtained for chlorhexidine-coated samples, with the average inhibition zone of 42.2 mm for Escherichia coli and 288.1 mm for Staphylococcus aureus. It is worth mentioning that both antibacterial agents are more active against Gram-positive bacteria. Finally, triclosan coated-samples showed the best results of the two antibacterial substances used. 

Chiappetta, D. A., Degrossi, J., Teves, S., D Aquino, M., Bregni, C. Sosnik, A., (2008). Triclosan-loaded poloxamine micelles for enhanced antibacterial activity against biofilm. EurJPharm Biopharm, 69, 535-545. 

Triclosan Parenteral Release, antibacterial activity Sustained release (Wang et al. 2010b)... 

Wang MJ, Coffer JL, Dorraj K, Hartman PS, Loni A, Canham LT (2010b) Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon. Mol Pharm 7(6) 2232-2239. doi 10.1021/mp 100227m... 

The most common use of 2-(2, 4 -dichlorophenoxy)-5-chlorophenol (2,4,4 -trichloro 2 -phenoxyphenol) is in the personal care products market, where it is commonly known as triclosan and is the active antibacterial in underarm deodorants. It has also found some acceptance as an antibacterial component of plastic mattress covers. 

Antibacterial soaps usually contain triclosan or triclocarban as the active antibacterial ingredient. 

This study shows that the activity of an antimicrobial treated ftibric varies depending on the test conditions used. This could be helpftd in determining the aid use of a trotted fabric. Treated ftibrics examined in this study containing triclosan, QACs or silva as an after-treatment proved to be active in moist conditions. Fabric containing inheioit silver or silver coated thread required soaking wet conditions. This is fine if the treated bric is to be used in an environment which is wet such as wound diesangs, where silver is currently the antibacterial of choice, as the presence of wound fluids or other secretions ionise the silver to its active form d. 

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