Trichophyton rubrum, infection

Fungal skin infections are primarily caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. Trichophyton rubrum accounts for more than 75% of all cases in the United States.36 To a lesser extent, Candida and other fungal species cause skin infections. With tinea infections, the causative dermatophyte typically invades the stratum corneum without penetration into the living tissues, leading to a localized infection. 

Aqueous extracts of ten medicinal plants were tested for their ability to inhibit Microsporum canis and Trichophyton rubrum, the ethiological agents of dermal fungal infections in humans [45]. Aqueous extract from the leaves of Inula viscosa Ait. =Dittrichia viscosa (L.) Greuter) produced detectable antifungal activity against these... 

Oxiconazole, an ergosterol synthesis inhibitor possessing antifungal activity, is used for topical treatment of dermal infections caused by Trichophyton rubrum and T. men-tagrophytes (tinea pedis, tinea cruris, and tinea corporis). 

Tolnaftate (1% cream, solution and gel) is indicated for treatment of tinea pedis (athlete s foot), t. cruris (jock itch), or t. corporis (ringworm) due to infection with Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Microsporum canis, M. audouini, and Epidermophy ton floccosum, and as treatment for tinea versicolor due to Malassezia furfur. 

Studies continued with two other topical agents for use in treatment of dermatophytoses. Tolnaftate (Tlnactln), as a 1 per cent powder, was found effective in both prevention and treatment of tinea pedis caused by Candida. Trichophyton and Epidermophyton.2 Haloprogin (Halotex), used topically as either a 1 per cent solution or as a cream, was found to be more effective than a placebo O and comparable to tolnaftate l in the treatment of experimental dermatophytlc infections (Trichophyton rubrum) and naturally occurring human Infections. 

Epidermophytonfloccosum infects the skin and nails but not the hair, whereas different species of the genus Trichophyton display both geographical and anatomical variations. For example, T. rubrum is currently the most common dermatophyte of... 

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