Trichophyton infection, treatment

Miconazole nitrate, previously shown to be effective in topical treatment of Trichophyton infections, was effective when used topically for 1 to 5 weeks as a 2 cream in kk of k6 cases of Candida vaginitis, but it was without effect in 2 cases of vaginal Torulopsis glabrata. ... 

Antifungal spectrum The drug is principally fungistatic. It is effective only against the dermatophytes—Trichophyton. Microsporum. and Epidermophyton. It is used in the treatment of severe tinea infections that do not respond to other antifungal agents. 

Itraconazole 100 mg/day has been studied in 24 children with Trichophyton tonsurans tinea capitis (51). Itraconazole was well tolerated, but 15 children required re-treatment due to persistent infection. 

Tolnaftate is a synthetic antifungal agent with a narrow spectrum of activity which is limited to dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.). It could be used to treat mild localized dermatophytic infection. For topical application to dogs, tolnaftate is formulated as a 1% cream containing both polyethylene glycol and propylene glycol. The powder aerosol preparation is less likely to be effective for treatment, but could be applied to prevent spread of the infection. 

An evaluation of microcrystalline griseofulvln therapy (oral) in scalp ringwoim using 32R patients emphasizes that successful therapy requires different treatment schedules for nonfluorescent Trichophyton induced infections and those caused by Microsporum species. Althou griseofulvln (iv) is usually given orally (as above) a recent report discloses successful topical treatment of cases of superficial dermato-phytosis with a 5 griseofulvln ointment. 

Oxiconazole, an ergosterol synthesis inhibitor possessing antifungal activity, is used for topical treatment of dermal infections caused by Trichophyton rubrum and T. men-tagrophytes (tinea pedis, tinea cruris, and tinea corporis). 

Tolnaftate (1% cream, solution and gel) is indicated for treatment of tinea pedis (athlete s foot), t. cruris (jock itch), or t. corporis (ringworm) due to infection with Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Microsporum canis, M. audouini, and Epidermophy ton floccosum, and as treatment for tinea versicolor due to Malassezia furfur. 

C42H,, sN024, Mr 1258.57, powder, (a], -2.6° (DMSO). A. A is the first known strong inhibitor of aflatoxin biosynthesis, also effective for the treatment of infections with Candida and Trichophyton sp. and Staphylococcus aureus. 

Miconazole nitrate, l-[2,4-dichloro-0-<2,4-dichlorobenzyloxy)phenethyl]imidazoIe, is reported effective both orally and topically in experimental infections of guinea pigs caused by Trichophyton mentagrophytes, T. amis, and C. albicans. In humans it was very effective in the topical treatment of tinea pedis caused by a variety of Trichophyton sp. ... 

A 1 cream formulation of myxin was an effective treatment of experimental Trichophyton mentagrophytes infections on guinea pigs however, 3% formulations of several closely related phenazine derivatives were ineffective.128... 

Studies continued with two other topical agents for use in treatment of dermatophytoses. Tolnaftate (Tlnactln), as a 1 per cent powder, was found effective in both prevention and treatment of tinea pedis caused by Candida. Trichophyton and Epidermophyton.2 Haloprogin (Halotex), used topically as either a 1 per cent solution or as a cream, was found to be more effective than a placebo O and comparable to tolnaftate l in the treatment of experimental dermatophytlc infections (Trichophyton rubrum) and naturally occurring human Infections. 

Dermatophyte fungi are moulds that spedfically infect the keratinised layers of the skin by virtue of their ability to degrade keratin. Three genera, Epidermophyton, Miao-sporum and Trichophyton, are responsible for causing ringworm or tinea infections (dermatophytosis). Griseofulvin is used exclusively for the oral treatment of dermatophyte infections where topical therapies have failed or are inappropriate. 

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