Tributyl tin oxide

A mixture of 23.4 g (39.3 mmol) of bis[(tributyl)tin] oxide and 11.6 g (81.7 mmol) of 4,6-dimethyl-l-hepten-4-ol is heated at 220 CC for 10 h in a three-necked flask equipped with a 12-cm Vigreux column, a condenser, a thermostat, and separating funnel. During this time a further 11.6 g (81.7 mmol) of 4,6-dimethyl-1-hcp-ten-4-ol are added dropwisc, and 4-methyl-2-pentanone (approx. 16 g) distilled out. The residue is distilled yield 11.5 g (88%) bp 92-93 °C/0.3 Torr. 

Fractional separation of tin compounds used as stabilisers in PVC was based on substoichiometric isotope dilution analysis [446]. The tin compounds were isolated by extraction and complexed with salicylideneamino-2-thiophenol, followed by controlled addition of y-irradiated tributyl tin oxide and measurement of the y-activity. PVC containing a nominal 0.63% (Bu Sn analysed 0.614 0.016% in nine determinations. 

Hamasaki and coworkers87 investigated the genotoxicity of 14 organic tin compounds (methyl-, butyl- and phenyltins) and inorganic tin (SnCU) on Escherichia coli and on Bacillus subtilis. Dibutyltin dichloride, tributyltin chloride, tributyltin chloride, bis(tributyl-tin)oxide, dimethyltin dichloride and trimethyltin chloride were all found to be genotoxic. 

Walsh, G.E., L.L. McLaughlin, M K. Louie, C.H. Deans, and E.M. Lores. 1986b. Inhibition of arm regeneration by Ophioderma brevispina (Echinodermata, Ophiuroidea) by tributyl tin oxide and triphenyltin oxide. Ecotoxicol. Environ. Safety 12 95-100. 

Treatment of benzyl 3, 4 -0-isopropylidene-P-lactoside with 3 molar equiv. of bis(tributyl)tin oxide and subsequent reaction with benzyl bromide gave a complex mixture of products. When benzylation was carried out in the presence of tetrabutylammonium bromide or TV-methylimidazole, 50% of the 2-O-benzyl derivative was obtained after some hours. After 7 days, the 2,6,6 -tri-0-benzyl derivative was the main product (38%) [150]. 

Mori Y, lesato K, Ueda S, et al. 1984. Renal tubular disturbances induced by tributyl-tin oxide in guinea pigs A secondary Fanconi syndrome. Clin Nephrol 21 118-128. 

BIS(TRIBUTYLSTANNYL)OXIDE see BLL750 BIS(TRIBUTYL TIN)OXIDE see BLL750 BIS(TRIBUTYLTIN)SULFIDE see HCA700 BIS(TRI-N-BUTYLZINN)-OXYD (GERMAN) see BLL750... 

Many antimicrobial products that were formerly used with textiles are now strictly regulated because of their toxicity and potential for environmental damage. Products such as copper naphthenate, copper-8-quinolinate, and numerous organo mercury compounds fall into this category. Other materials that still have limited use in specialised areas include tributyl tin oxide (deleted in many countries. Fig. 15.1a), dichlorophene (Fig. 15.1b) and 3-iodopropynylbutyl carbamate (Fig. 15.1c). These products typically show a very broad spectrum of activity against bacteria and fungi, but suffer from application and durability problems. 

A very selective method of oxidizing secondary alcohols is bromino-lysis of tributyltin ethers prepared by the treatment of hydroxy compounds with bis(tributyl)tin oxide. The reaction is regio- and stereospecific and is an important means of oxidizing unprotected glycosides [734]. 

Biological and biochemistry Biocides, bactericides, fungicides, algaecides, antifouling. Tributyl tin oxide, formaldehye, tiuodiazine-duone, oxazolodimes, titiophthalimide. 

Organotin pesticides, including tributyl tin oxide, a fungicide for above-ground applications. 

Tributyl Tin Oxides. These (Fig. 5.4—VI) have been useful in vinyls, polyurethanes, and marine paints. Use is decreasing because of worry about toxicity. 

This is an interesting question. Is this simply a solubility effect, or is it something else I conclude it is not simply a solubility effect because, at levels where the tributyl tin oxide is soluble, the activities of the sucrose compounds are higher. In the best tests, the sucrose compound is three times more effective with around a third the amount of tin in it. Most of the tests were carried out at concentrations where both the sucrose compounds and the reference organotin pesticides were completely dissolved and so the increased activities cannot simply be attributed to solubility effects. 

Tin (iv) alkoxides and oxides react similarly with alkyl and aryl isocyanates . On treating bis-tributyl tin oxide with two different isocyanates, isocyanurates 277 are obtained via repeated insertion reactions... 

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