Transcription mechanism

Chafila TA, Li N, Garcia-Lloret M. Kim HJ. Nel AE T-cell effector pathways in allergic diseases transcriptional mechanisms and therapeutic targets. J Allergy Chn Immunol 2008 121 812-823 quiz 824-815. 

Thus the intrinsic timer in OPCs is complex. Some proteins increase over time and others decrease, and both transcriptional and post-transcriptional mechanisms seem to be involved. 

A number of stimuli are known to act as inducers of TNF production (Table 9.6). Bacterial LPS represents the most important inducer, and TNF mediates the pathophysiological effects of this molecule. TNF biosynthesis is regulated by both transcriptional and post-transcriptional mechanisms. Macrophages appear to express TNF-a mRNA constitutively, which is translated only... 

Figure 8.2. PPAR-7 gene transcription mechanism and its bioiogic effects.

Takahashi That is a good point. The transcriptional feedback loop has been selected because of all the downstream outputs that it controls. It would be hard to do this with a post-transcriptional mechanism. 

CYP2E1 mRNA, suggesting a post-transcriptional mechanism for the increase in renal... 

A large variety of inhibitors of RNA synthesis have been identified. Some of these inhibitors have proved useful in elucidating transcription mechanisms, and some have facilitated selection for superior mutant strains with enzymes that are resistant to their inhibition. The inhibitors fall into three classes (fig. 28.22). 

Nolan-Willard, M., Berton, M.T., Tucker, P. (1992). Coexpression of p and y 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome. Proc. Natl. Acad. Sci. USA 89, 1234-1238. 

Lee JE, Safe S. 2001. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem Pharmacol 62 1113-1124. 

Lassegue, B., Alexander, R. W., Nickenig, G., et al. 1995. Angiotensin II down-regulates the vascular smooth muscle ATI receptor by transcriptional and post-transcriptional mechanisms evidence for homologous and heterologous regulation. Mol Pharmacol 48 601-609. 

A second type of mechanism is illustrated by the malic enzyme and fatty synthetase systems. In such systems the effect of T3 on the accumulation of the specific mRNAs does not seem to depend only on direct gene activation by the T3-nuclear receptor. An amplification post-transcriptional mechanism seems to contribute to the accumulation of the specific mRNAs. Stabilization of the mRNA level is also differently modulated by other hormones and by the diet. 

T3 seems to act through a post-transcriptional mechanism that perhaps does not involve the classical thyroid hormone receptor [4], This is supported by the finding that T4 and rT3 are even more potent regulators of the type II deiodinase [81,89-91],... 

Figure 8 Schematic diagram of the nuclear hormone receptor transcription mechanism...

Figure 5.25. Transcription Mechanism of the Chain-Elongation Reaction Catalyzed by RNA Polymerase. Table 5.3. Base composition (percentage) of RNA synthesized from a viral DNA template...

Wang HY, Xin Z, Tang H, Ganea D. Vasoactive intestinal peptide inhibits IL-4 production in murine T cells by a post-transcriptional mechanism. J Immuno 1996 156 3243-53. 

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