Oct 3/4 transcription factors

Abdulkadir SA, Krishna S, Thanos D et al. (1995) Functional Roles of the Transcription Factor Oct-2A and the High Mobility Group Protein I A7 in HLA-DRA Gene Expression. J Exp Med 182(2)487-500... 

The origin and identity of NSCs remain source of debate and controversy [1]. Though recent reports further support an astroglial origin for newly-generated neuronal cells [25-29], NSCs are yet to be unequivocally identified in the adult brain. There are currently no specific markers of adult NSCs. The intermediate neurofilament nestin, the transcription factors sox-2, oct-3/4, and the RNA binding protein Musashi 1 are markers for neural progenitor and stem... 

Nasir ud D. Oct-2 DNA binding transcription factor functional consequences of phosphorylation and glycosylation. Nucleic Acids 36. 

DNA-binding sequences before these sequences become sequestered into nu-cleosomes, which are inherently transcriptionally repressive (Wolffe, 1991, 1994). Consistent with this proposal is the observation that confocal microscopy indicated that the nuclear concentration of transcription factors such as TATA-box binding protein (TBP) and Spl (Worrad et al., 1994) as well as oct-4 and etl-1 (Worrad and Schultz, unpublished observations) was higher in the male pronucleus than the female pronucleus. Such a difference could account for greater level of transcription supported by the male pronucleus. Nevertheless, it was also possible that the transcriptional capacity of the female pronucleus was inherently less than that of the male pronucleus. This does not seem to be the case, however, since BrUTP incorporation by the female pronucleus in a parthenogenetically activated egg was equivalent to that of the combined BrUTP incorporation of the male and female pronuclei in a fertilized egg (Aoki et al., 1997). Likewise, the amount of TBP sequestered by the female pronucleus in a parthenogenetically activated egg was much greater than that of a fertilized egg and essentially equivalent to that present in both the male and female pronuclei. Thus, when the female pronucleus does not have to compete with the male pronucleus for transcription factors, the female pronucleus can readily sequester the maternally derived transcription factors. 

Browne P, Petrosyan K, Hernandez A, et al. The B-cell transcription factors BSAP, Oct-2, and BOB.l and the pan-B-cell markers GD20, GD22, and GD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol. 2003 120 767-777. 

Nagy M, Chapuis B, Matthes T. Expression of transcription factors Pu.l, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells. Br J Haematol. 2002 116 429-435. 

A key regulatory protein called Oct-3/4, a transcription factor protein, is involved in the determination of the development of ES cells. 

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