TRAF, Tumor necrosis factor

TRAF, tumor necrosis factor-associated factor TTRAP, TRAFATNF-R receptor associated protein. System was operational in ancestral mollusks (Yang J et al Dev Comp Immunol 2011 35 827-34). TRAF6 and p62 sequestosome suppress NEMO by ubiquitination depletion of p62 by siRNA abrogates TRAF activity. NFkB activation depends on the ubiquitinational state of NEMO (Zotti T et al Mol Immunol 2014 58 27-31). TTRAP inhibits NFkB activation (Pype S et al J Biol Chem 2000 275 18586-93). 

TRAF Tumor necrosis factor receptor-associated factor... 

Tumor necrosis factor receptor associated factors are a group of at least 6 proteins (TRAF 1-6), which are major signal transducers for the TNF receptor superfamily and the the interlukin-1 receptor/toll-like receptor (IL-1R/ TLR) superfamily. TRAF proteins are characterized by the presence of the TRAF domain at the the C-terminus,... 

Pullen, S. S., Dang, T. T. A., Crate, J. J., and Kehry, M. R. (1999). CD40 signalling through tumor necrosis factor receptor-associated factors (TRAFs). J. Biol. Chem. 274, 14246-14254. 

Arch, R. H., R. W. Gedrich, and C. B. Thompson, Tumor necrosis factor receptor-associated factors (TRAFs) — a family of adapter proteins that regulates life and death. Genes Dev, 1998, 12(18), 2821-30. 

Bradley JR, Prober JS. 2001. Tumor necrosis factor receptor associated factors (TRAFs). Oncogene. 20 6482-6491. 

Hacker, H., Vabulas, R.M., Takeuchi, O., Hoshino, K., Akira, S. and Wagner, H. (2000) Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med., 192, 595-600. 

Henkler, F., Baumann, B., Fotin-Mleczek, M., Weingartner, M., Schwenzer, R., Peters, N., Graness, A., et al., Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-l from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation. J Biol Chem 278 (2003) 29216-29230. 

Damay, B. G., Ni,J., Moore, P. A., and Aggarwal, B. B. (1999). Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and... 

Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., and Watanabe, T. (1997). Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J. Biol Cham. 272, 2042-2045. 

TRAF TNF [tumor necrosis factor] receptor-associated factors... 

TNK = TANK-binding kinase TANK = TRAF-family member-associated NFkB activator TRAP- (tumor necrosis factor receptor-associated factor-) associated nuclear factor kappa B activator STEAP, six transmembrane epithelial antigen, prostate. 

TNF-a is a membrane-bound protein that once cleaved may act as a cytokine similar in function to IL-1 (Malemud, 2004). TNF-a is proteolytically cleaved by MMPs then binds with TNF-Rl or TNF-R2, both found on osteoblasts and chondrocytes (Malemud, 2004) Once bound the TNF receptor and ligand complex form a trimer and begins the signaling pathway. TNF receptors associate with tumor necrosis factor receptor-associated death domain protein (TRADD) to initiate the signaling pathways through FADD and TRAF2/5 (Yoon and Fisher, 2007, Nanes, 2003). TRAF 2/5 lead to the activation of the NF-kB and MAPK pathways (Yoon and Fisher, 2007, Malemud, 2004, Nanes, 2003). The FADD pathway initiates apoptosis through the activation of the caspase pathway. 

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