Toxicity testing potential human adverse effects predicted

Sensitization of the Skin or Respiratory System Evidence of adverse effects in humans Weight of evidence demonstrates potential for adverse effects in humans GHS Category 1 —(skin or respiratory) or Positive responses in predictive Human Repeat Insult Patch Tests (HRIPT) (skin) Suggestive animal studies Analog data or Chemical class known to produce toxicity No basis for concern identified... 

Evaluation of new pharmaceuticals, pesticides, and the like for developmental toxicity is required by law. Such testing is actually a special type of toxicity testing and the rules for these studies are based on a few generally accepted principles and a number of assumptions. The principles are listed in this section and the assumptions implicit in these studies are discussed. The overall predictive ability of the animal studies to give reliable indication of potential adverse effects in humans is then presented. 

Cerium sulfide pigments (NEOLOR ) are almost completely insoluble in water, and the cerium ion shows effectively no toxicity (acute or chronic). As predicted, cerium sulfide pigments have shown no risk to humans or the environment. Acute oral toxicity LD50 rat, oral >5000 mg/kg l Tests for irritation to the skin, eyes, or mucous membranes have also shown no adverse effects, as have tests for potential skin sensitivity l... 

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