Toxicity potassium iodide

There is an additive bone marrow depression when methimazole or propylthiouracil is administered with otiier bone marrow depressants, such as the antineo-plastic drugs, or witii radiation therapy. When methimazole is administered with digitalis, there is an increased effectiveness of the digitalis and increased risk of toxicity. There is an additive effect of propylthiouracil when the drug is administered with lithium, potassium iodide, or sodium iodide When iodine products are administered with litiiium products, synergistic hypotiiyroid activity is likely to occur. 

Potassium iodide has been widely used in asthma and chronic bronchitis as an expectorant. There is considerable controversy about its efficacy. It should not be used in adolescent patients because of its potential to aggravate and induce acne and its effect on the thyroid gland. In view of its doubtful efficacy and definite toxicity, it would be preferable if physicians stopped prescribing it as an expectorant. 

Potassium iodide is unlikely to result in acute toxicity. Manifestations of a hypersensitivity reaction may include angioedema, cutaneous and mucosal hemorrhage, urticaria, fever, arthralgia, enlarged lymph nodes, and eosinophilia. In patients with chronic urticaria or systemic lupus erythematosus, hypocomplementemic vasculitis may be precipitated. 

Iodides and Other Inoi anic Compounds. Inorganic compounds such as potassium iodide [7681-11 -0]y hydriodic acid [10034-85-2]y antimony potassium tartrate [28300-74-5]y and ammonium chloride [12125-02-9] are thought to act by gastric reflex stimulation. Of these, only the iodides have been studied to any appreciable extent (13). A number of toxic reactions have been associated with both antimony potassium tartrate (14) and inorganic iodides (15,16). Reaction of iodine with glycerol [56-81-5] (qv) produces a stable oiganic iodide mixture, iodinated glycerol [5634-39-9] (14), which has expectorant properties. Formulations of (14) contain no free or ionic iodine, but iodine is released metaboHcally. 

Formula (CH3)2CH0C(0)00C(0)0CH(CH3)2 Properties Colorless cryst. solid or liq. misc. with aliphatic, aromatic, and chlorinated hydrocarbons, esters, ethers pract. insol. in water m.w. 206.22 dens. 1.080 (15.5/4 C) m.p. 8-10 C rapid decomp. 63 F ref. index 1.4034 (20 C) Toxicology LD50 (oral, rat) 2140 mg/kg, (skin, rabbit) 2025 mg/kg mod. toxic by ing. and skin contact primary severe eye irritant TSCA listed Precaution Dangerous fire risk unstable above IOC impact- and heat-sensitive explosive spontaneous decomp. R.T. releases flamm. and corrosive prods. explodes on heating explodes on contact with amines or potassium iodide, possibly organics Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and fumes NFPA Health 0, Flammability 4, Reactivity 4 Storage Store in open containers low temps, with adequate ventilation Uses Low-temp, polymerization catalyst initiator for polymerization of unsat. monomers, PVC in food-pkg. adhesives polymerization catalyst in mfg. of paper/paperboard in contact with aq./fatty foods... 

---