Toxicity, consolidant

The early promise of wide applications for beryllium has not materialised, despite improvements in purity and more efficient means of consolidation such as isostatic hot pressing, because of the metal s toxicity, brittleness and cost. It is now chiefly of interest in the specialised fields of aerospace and nuclear applications. BrushWellman is currently the sole commercial primary producer of beryllium metal in the West. 

Rydell, CD. 1990. Written communication (March 27) to Barry L. Johnson. Agency for Toxic Substances and Disease Registry, regarding North Dakota Air Contaminant Limits. North Dakota State Department of Health and Consolidated Laboratories, Bismarck, ND. 

Limnofix In situ Sediment Treatment (LIST) technology is offered by Limnofix, Inc., a Colder Associates Company. The technology allows for the in situ treatment of contaminated sediment in surface waters. LIST enhances bioremediation of organic contaminants oxidizes sediments to control odor, nutrient release, or sulfide toxicity and produces stable marine sediment surfaces via consolidation and flocculation. 

Endogenous BDNF-TrkB signaling in glutamate-mediated neurotransmission may be involved in consolidation of information at the synapse. Recent studies also indicate that sustained synthesis of the immediate early gene Arc, activity-regulated cytoskeleton-associated protein, during glutamate toxicity protracts the... 

SAFETY PROFILE Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion pulmonary consolidation. Used as a central nervous system depressant, hypnotic, and sedative. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES. 

Roll-up. The agglomeration, summarization, or consolidation of data into a summary presentation. Roll-up often involves summarizing data at a given level in a data hierarchy. Examples would include the average of several ED values, or a simpleyes/no indication that toxicity data for a given structure exists somewhere in the database. 

Small Areas Consolidate as much solid material as possible and place in appropriate containers. Care should be made to minimize the aerosolization of agent. Employ vacuum devices equipped with High Efficiency Particulate Air (HEPA) filters to remove as much dust as possible. If necessary, wash (wet-vac) with copious amounts of alkaline detergent and water. Do not use bleach or detergents containing bleach as they may interact with agents to produce toxic decomposition products. Porous surfaces may be difficult to decontaminate. 

Notes with appreciation the co-operative relationship established between the United Nations, the World Health Organization and the United Nations Environment Programme International Register of Potentially Toxic Chemicals for the preparation of the Consolidated List ... 

The duration of consolidative chemotherapy has been evaluated in several studies. In advanced ovarian cancer, the administration of five cycles of cyclophosphamide, cisplatin, and doxorubicin was equally effective and less toxic as compared to 10 cycles of chemotherapy. Six to nine cycles of chemotherapy has become the standard approach and results in clinical response rates of approximately 60% to 70%, with 5-year survival rates of 10% to 20%. Because approximately 50% of patients with a confirmed pathologic response will ultimately relapse, chemotherapy may be extended for two or three cycles beyond best response. ... 

Sanz M, Martin G, Raynon C, et al. A modified AIDA protocol with anthracycUne-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML-RARa-positive acute promyelocytic leukemia PETHEMA group. Blood 1999 94 3015—3021. 

Ahmad Khan, H. (2007). Benzene s toxicity A consolidated short review of human and animal studies. Hum Exp Toxicol 26, 677-685. 

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