Toluene sulphon amide

Nitroso-piperidine—Nitro-toluene—Azo-benzene, introduction of hydroxyl groups — Toluene-sulphone-amides— Saccharine—p-Nitro-o-toluene-sulphone - amide—Oxida -tion of aromatic oxy-carboxylic acids.76-78... 

According to a patent benzoyl-sulphone-imides can be prepared by the electrolytic oxidation of toluene-sulphone-amides for example, o-benzoyl-sulphone-imide, or saccharine, from o-toluene-sulphone-amide ... 

The corresponding p-compound, and p-nltro-o-toluene-sulphone-amide, ... 

A number of basic materials such as hydroxides, hydrides and amides of alkaline and alkaline earth metals and metal oxides such as zinc oxide and antimony oxide are useful catalysts for the reaction. Acid ester-exchange catalysts such as boric acid, p-toluene sulphonic acid and zinc chloride are less... 

It is generally more convenient to employ the solid toluene-p-sulphonyl chloride (m.p. 69 °C) rather than the liquid benzenesulphonyl chloride. Moreover, the benzenesulphonamides of certain secondary amines are oils or low melting point solids that may be difficult to crystallise the toluene-p-sulphon-amides usually have higher melting points and are more satisfactory as derivatives. ... 

Mixtures of primary, secondary and tertiary amines can usually be separated by Hinsberg s method. This is based on the fact that reaction with benzene-sulphonyl (or toluene-p-sulphonyl) chloride converts primary amines into alkali-soluble sulphonamides, secondary amines into alkali-insoluble sulphon-amides and leaves tertiary amines unaffected. 

Toluene-p- sulphon- amide °C Phenyl- thiourea °C 1-Naphthyl- thiourea °C Picrate °C /V-Substi-tuted phthal-imide °C Benzamide °C Acetamide °C... 

Acetylamino-p-toluene sulphonic acid amide Cyclohexylamine... 

Toluene-p- sulphon- amide °C Benzylidene derivative °C Picrate °C 3-Nitro- 2,4-Dinitro- Formyl Phenyl phthalimide phenyl derivative thiourea °C derivative °C °C °C ... 

According to Tamura and his co-workers, the easily prepared methylsul-phinyl substituted amides (189) may be cyclized by treatment with toluene sulphonic acid. Similarly, the methylthio-substituted halides (190), prepared from the same precursor, cyclize to the same products under influence of a Lewis acid. These methods are mild and proceed in good yields and, when n = 0, provide a useful synthesis of the oxindoles (191). 

Cl4H19N3O2S, N-(1,2,3,5-Tetramethyl-4-pyrazolio)toluene-p-sulphon-amidate, 43B, 278... 

The results of surface coating 10 different polymers with HE res. ES-HS can be seen in Table 1. GAG type 2 and regioselective modified heparin derivative immobilisation was achieved by amide bond formation between carboxyl groups on the polymer surface and amino groups in the GAG chain or vice versa carboxyl groups were activated by the water soluble carbodiimide N-cyclohexyl-N -(2-morpholinoethyl)carbodiimide-methyl-p-toluene sulphonate (CME-CDl). 

Toluene-p-sulphonchloro-sodio-amide ( Chloramine-T ), CHjC HjSO-NNaCh. H.O, and Toluene-p-sulphon-dichloro-amide ( Dickloramine-T ), CH3C H4S02Na2. 

Esters, Carboxylic Acids, and Ethers.—The rates of hydrolysis of 3(3- and 6(3-acetoxy-4 ,5 -epoxides and 1 a-acetoxy-2(3,3 (3-epoxides were observed to be accelerated relative to those acetates not containing a neighbouring epoxide group.24 Bile acid methyl esters were readily prepared from the carboxylic acids by reaction with methanol in the presence of toluene-p-sulphonic acid.25 Bile acids were readily converted into the amino-amides (14) by successive reaction with Bu N-... 

The alkylation of diphenyl A alkylphosphinic amides via the amide anion and subsequent cleavage of the iVW-dialkylamide with toluene-p-sulphonic acid is a valuable, if not preferable, alternative to the preparation of secondary amines through the Hinsberg procedure. ... 

The product of sulphonation of toluene is a mixture of p- and o-toluensulphonic acids. The acids are converted into the sulphonyl chlorides, which may be separated, as the para compound is a solid and the ortho compound is a liquid. The liquid chloride is next converted by ammonia into the amide, which is oxidized in aqueous solution with potassium permanganate. On acidifying the solution saccharin is obtained. 

Equation (a) Toluene-pam-sulphonamide on dissolution in an excess of sodium hypochlorite solution gives rise to the formation of toluene-p-sulphon-chloro-sodio-amide (I), which being water-soluble does not ordinarily crystallise out unless and until very concentrated solutions are employed. 

Equation (6) At this particular stage if a weak acid, e.g., acetic acid is added to the resulting solution of (I) above, the latter compound (i.e., I) readily interacts with the hypochlorus acid yielding the Dichloramine-T (or Toluene-p-sulphon-dichloro amide), which being water-insoluble gets separated rapidly. 

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